PMID- 8399074
OWN - NLM
STAT- MEDLINE
DCOM- 19931105
LR  - 20191101
IS  - 1049-8834 (Print)
IS  - 1049-8834 (Linking)
VI  - 13
IP  - 10
DP  - 1993 Oct
TI  - Depletion of lipoprotein lipase after heparin administration.
PG  - 1391-6
AB  - Some or most of the turnover of lipoprotein lipase (LPL) occurs by dissociation 
      from vascular endothelial sites in extrahepatic tissues and further degradation 
      in the liver. Heparin greatly enhances this dissociation and delays but does not 
      abolish uptake in the liver, raising the possibility that heparin could lead to 
      accelerated catabolism of functional LPL. To investigate this, we determined time 
      curves for heparin (anti-factor Xa activity) and for LPL and hepatic lipase after 
      injection in rats of two doses of conventional unfractionated heparin (UFH) or 
      low-molecular-weight heparin (LMWH). The high dose (250 U/kg) of both heparins 
      resulted in similar initial levels of LPL activity in plasma, but at 30 minutes 
      the activity with LMWH had declined by more than 80%, whereas with UFH it 
      remained essentially unchanged during this time. In contrast, time curves for 
      heparin activity in blood were similar for the two heparins. The low dose (50 
      U/kg) led to lower initial levels of LPL activity with LMWH in spite of slower 
      elimination of heparin activity from the blood. These results agree with previous 
      studies that indicate that LMWH has a similar ability as UFH to release LPL, but 
      a lesser ability to delay its removal by the liver. Only slight differences were 
      noted in the time curves for hepatic lipase with the two heparins. To assess the 
      possible depletion of the lipases, we administered a second large dose of 
      conventional heparin. One hour after the first injection, the second injection 
      resulted in lower plasma LPL activities in all four groups.(ABSTRACT TRUNCATED AT 
      250 WORDS)
FAU - Chevreuil, O
AU  - Chevreuil O
AD  - Department of Medical Biochemistry and Biophysics, University of Umea, Sweden.
FAU - Hultin, M
AU  - Hultin M
FAU - Ostergaard, P
AU  - Ostergaard P
FAU - Olivecrona, T
AU  - Olivecrona T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arterioscler Thromb
JT  - Arteriosclerosis and thrombosis : a journal of vascular biology
JID - 9101388
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.1.1.3 (Lipase)
RN  - EC 3.1.1.34 (Lipoprotein Lipase)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Heparin/*pharmacology
MH  - Heparin, Low-Molecular-Weight/pharmacology
MH  - Lipase/blood
MH  - Lipoprotein Lipase/*blood
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 10.1161/01.atv.13.10.1391 [doi]
PST - ppublish
SO  - Arterioscler Thromb. 1993 Oct;13(10):1391-6. doi: 10.1161/01.atv.13.10.1391.