PMID- 8399075
OWN - NLM
STAT- MEDLINE
DCOM- 19931105
LR  - 20191101
IS  - 1049-8834 (Print)
IS  - 1049-8834 (Linking)
VI  - 13
IP  - 10
DP  - 1993 Oct
TI  - Biphasic effects of low-molecular-weight and conventional heparins on chylomicron 
      clearance in rats.
PG  - 1397-403
AB  - Chylomicrons labeled in vivo with [14C]triglycerides and [3H]retinyl esters were 
      injected in rats at a series of times after administration of conventional 
      unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), or saline. In 
      saline controls the clearance of both chylomicron triglycerides and retinyl 
      esters seemed to follow exponential courses, with half-lives of about 5 and 10 
      minutes, respectively. Five minutes after administration of LMWH or UFH, the 
      triglyceride clearance rates were dramatically increased and were associated with 
      an increased appearance of the radiolabel in circulating free fatty acids (FFAs). 
      The clearance of [3H]retinol radioactivity, ie, chylomicron particles, was also 
      enhanced 5 minutes after heparin injection. From 75% to 90% disappeared from the 
      circulation within the first 5 minutes. Their continued disappearance was much 
      slower, with a slope similar to that of the saline-treated rats. Hence, it was as 
      if a new, rapid exponent had been added to the disappearance curve that accounted 
      for most of the particle clearance. Injection of chylomicrons 1 hour after the 
      heparins resulted in substantially slower clearance compared with saline-treated 
      controls of both triglyceride and retinol radioactivity in rats given a high dose 
      of LMWH or a low dose of either heparin. Appearance of label in plasma FFAs was 
      also decreased, suggesting that impeded lipolysis was responsible, at least in 
      part, for the impeded chylomicron clearance. Four and 24 hours after heparin 
      injection all studied parameters of chylomicron clearance had returned to 
      normal.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Chevreuil, O
AU  - Chevreuil O
AD  - Department of Medical Biochemistry and Biophysics, University of Umea, Sweden.
FAU - Hultin, M
AU  - Hultin M
FAU - Ostergaard, P
AU  - Ostergaard P
FAU - Olivecrona, T
AU  - Olivecrona T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arterioscler Thromb
JT  - Arteriosclerosis and thrombosis : a journal of vascular biology
JID - 9101388
RN  - 0 (Chylomicrons)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Triglycerides)
RN  - 11103-57-4 (Vitamin A)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Chylomicrons/*pharmacokinetics/pharmacology
MH  - Heparin/*pharmacology
MH  - Heparin, Low-Molecular-Weight/*pharmacology
MH  - Lipolysis
MH  - Rats
MH  - Time Factors
MH  - Triglycerides/pharmacokinetics
MH  - Vitamin A/pharmacokinetics
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 10.1161/01.atv.13.10.1397 [doi]
PST - ppublish
SO  - Arterioscler Thromb. 1993 Oct;13(10):1397-403. doi: 10.1161/01.atv.13.10.1397.