PMID- 8401259
OWN - NLM
STAT- MEDLINE
DCOM- 19931110
LR  - 20091119
IS  - 1066-5099 (Print)
IS  - 1066-5099 (Linking)
VI  - 11 Suppl 2
DP  - 1993 Jul
TI  - The hepatocyte growth factor and its receptor.
PG  - 22-30
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is secreted by cells of 
      mesodermal origin and shows powerful mitogenic, motogenic and morphogenic 
      activities on epithelial and endothelial cells. It is a heparin-binding 
      polypeptide with an alpha/beta heterodimeric structure, showing structural 
      homologies with enzymes of the blood clotting cascade. HGF binds with high 
      affinity to the receptor encoded by the MET protooncogene (p190MET). The MET 
      receptor is a heterodimer of two disulfide-linked subunits (alpha and beta); the 
      alpha subunit is extracellular, while the beta is transmembrane and endowed with 
      tyrosine kinase activity. The HGF-triggered signalling is mediated by different 
      cytoplasmic effectors, including phosphatidylinositol 3-kinase, phospholipase 
      C-gamma, and Src-related tyrosine kinases. p190MET is expressed in several normal 
      epithelial tissues (e.g., liver, gastrointestinal tract, kidney) and is often 
      overexpressed in neoplastic cells. p190MET expression has been reported also in 
      central nervous system microglia, a monocyte-derived cell population. We recently 
      found that p190MET is expressed in selected peripheral blood cell populations, 
      such as macrophages. The amount of both mRNA and protein is barely detectable, 
      while it is dramatically increased upon activation. These findings suggest that 
      HGF may play a role in hemopoietic cell signaling, during activation and 
      differentiation of blood cell lineages.
FAU - Galimi, F
AU  - Galimi F
AD  - Department of Biomedical Sciences and Oncology, University of Turin, School of 
      Medicine, Italy.
FAU - Brizzi, M F
AU  - Brizzi MF
FAU - Comoglio, P M
AU  - Comoglio PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Carcinoma/metabolism
MH  - Cell Division
MH  - Cell Movement
MH  - Epithelial Cells
MH  - Epithelium/metabolism
MH  - Gene Expression Regulation
MH  - Genes
MH  - Hepatocyte Growth Factor/genetics/metabolism/*physiology
MH  - Humans
MH  - Macrophages/metabolism
MH  - Mice
MH  - Mitosis
MH  - Monocytes/metabolism
MH  - Neoplasm Proteins/metabolism
MH  - Neuroglia/metabolism
MH  - Organ Specificity
MH  - Protein-Tyrosine Kinases/genetics/metabolism/*physiology
MH  - Proto-Oncogene Proteins/genetics/metabolism/*physiology
MH  - Proto-Oncogene Proteins c-met
MH  - Proto-Oncogenes
MH  - Rabbits
MH  - Rats
MH  - Receptor Protein-Tyrosine Kinases/genetics/metabolism/*physiology
MH  - Receptors, Cell Surface/genetics/metabolism/*physiology
MH  - Signal Transduction
RF  - 54
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 10.1002/stem.5530110805 [doi]
PST - ppublish
SO  - Stem Cells. 1993 Jul;11 Suppl 2:22-30. doi: 10.1002/stem.5530110805.