PMID- 8403368
OWN - NLM
STAT- MEDLINE
DCOM- 19931102
LR  - 20190830
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 74
IP  - 1
DP  - 1993 Jul 16
TI  - Odor-induced sexual maturation and expression of c-fos in the olfactory system of 
      juvenile female mice.
PG  - 138-41
AB  - Exposure to the urine or soiled bedding odors of novel adult males is known to 
      accelerate puberty in juvenile female mice. To determine what part of the 
      olfactory system is activated by these odors, the expression of c-fos in the main 
      olfactory bulb (MOB) and the accessory olfactory bulb (AOB) of juvenile female 
      mice was examined after their exposure to male-soiled bedding, peppermint odor or 
      their own bedding. Fos-like immunoreactivity was found throughout the AOB of the 
      juvenile female mice exposed to the bedding odors of adult males for 3 h. In 
      contrast, dense staining was found in the granular cell layer of the MOB of mice 
      exposed to peppermint odors for 3 h, whereas mice exposed to their own bedding 
      failed to show immunostaining in the AOB and only slight or no staining in the 
      MOB. These results indicate that social odors stimulate the expression of c-fos 
      in the AOB while non-social odors activate the MOB. This method allows the 
      identification of individual cells activated by the different odors and will be 
      useful in locating other areas of the brain involved in the neuroendocrine 
      changes underlying odor-induced precocious puberty.
FAU - Schellinck, H M
AU  - Schellinck HM
AD  - Department of Psychology, Dalhousie University, Halifax, N.S., Canada.
FAU - Smyth, C
AU  - Smyth C
FAU - Brown, R
AU  - Brown R
FAU - Wilkinson, M
AU  - Wilkinson M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
GS  - c-fos
MH  - Animals
MH  - Female
MH  - Mice
MH  - *Odorants
MH  - Olfactory Bulb/*metabolism
MH  - Proto-Oncogene Proteins c-fos/*biosynthesis
MH  - Sexual Maturation/*physiology
MH  - Time Factors
EDAT- 1993/07/16 00:00
MHDA- 1993/07/16 00:01
CRDT- 1993/07/16 00:00
PHST- 1993/07/16 00:00 [pubmed]
PHST- 1993/07/16 00:01 [medline]
PHST- 1993/07/16 00:00 [entrez]
AID - 0165-3806(93)90094-Q [pii]
AID - 10.1016/0165-3806(93)90094-q [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 1993 Jul 16;74(1):138-41. doi: 
      10.1016/0165-3806(93)90094-q.