PMID- 8404536
OWN - NLM
STAT- MEDLINE
DCOM- 19931116
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 117
IP  - 4
DP  - 1993 Apr
TI  - Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the 
      trigeminal ganglion.
PG  - 1345-53
AB  - The cellular localization of mRNA for neurotrophin-4 (NT-4), a novel neurotrophic 
      factor, in the developing whisker follicles and skin of the embryonic rat is 
      demonstrated by in situ hybridization. Levels of NT-4 mRNA in the whisker pad 
      decrease between embryonic day 13 (E13) and E20, correlating in time with the 
      onset of naturally occurring neuronal death in the innervating trigeminal 
      ganglion. In addition to NT-4, brain-derived neuotrophic factor (BDNF) mRNA is 
      also shown to be expressed in the rat embryonic whisker follicles although in a 
      different cellular localization, which combined with previous data on the 
      expression of NGF and NT-3 mRNAs, shows that all four neurotrophins are expressed 
      during development of this structure. NT-4 protein is shown to elicit neurite 
      outgrowth from explanted embryonic trigeminal ganglia and to promote neuronal 
      survival of dissociated trigeminal ganglion neurons when cultured during the 
      phase of cell death. NT-4 and NT-3 mainly support different neuronal 
      subpopulations, whereas some NT-4-responsive cells appear to respond also to NGF 
      and BDNF. Analysis of mRNAs for members of the Trk family of neurotrophin 
      receptors in neurons rescued by different neurotrophins demonstrates the presence 
      of distinct neuronal subpopulations that respond to specific combinations of 
      these factors. Based on these results we propose that NT-4, together with the 
      other three neurotrophins, orchestrate the innervation of the different 
      structures of the developing whisker pad by the trigeminal ganglion, acting as 
      target-derived neurotrophic factors for different subpopulations of trigeminal 
      ganglion neurons.
FAU - Ibanez, C F
AU  - Ibanez CF
AD  - Department of Medical Chemistry II, Karolinska Institute, Stockholm, Sweden.
FAU - Ernfors, P
AU  - Ernfors P
FAU - Timmusk, T
AU  - Timmusk T
FAU - Ip, N Y
AU  - Ip NY
FAU - Arenas, E
AU  - Arenas E
FAU - Yancopoulos, G D
AU  - Yancopoulos GD
FAU - Persson, H
AU  - Persson H
LA  - eng
GR  - AG04418/AG/NIA NIH HHS/United States
GR  - NS09199/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Female
MH  - In Situ Hybridization
MH  - Nerve Growth Factors/genetics/*physiology
MH  - Nerve Tissue Proteins/genetics/*physiology
MH  - Neurotrophin 3
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/embryology
MH  - Trigeminal Ganglion/*embryology
MH  - Vibrissae/embryology
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 10.1242/dev.117.4.1345 [doi]
PST - ppublish
SO  - Development. 1993 Apr;117(4):1345-53. doi: 10.1242/dev.117.4.1345.