PMID- 8405112
OWN - NLM
STAT- MEDLINE
DCOM- 19931109
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 238
IP  - 2-3
DP  - 1993 Jul 20
TI  - Alpha-atrial natriuretic peptide attenuates ethanol withdrawal symptoms.
PG  - 417-9
AB  - Mice were rendered tolerant to and dependent on ethanol with an ethanol-liquid 
      diet for 14 days. Five hours after withdrawal from ethanol, withdrawal symptoms 
      were analyzed by scoring handling-induced convulsions. Intracerebroventricular 
      (i.c.v.) injection of alpha-atrial natriuretic peptide (alpha-ANP) attenuated, 
      whereas that of an antiserum against alpha-ANP (anti-ANP) intensified the 
      severity of handling-induced convulsions.
FAU - Kovacs, G L
AU  - Kovacs GL
AD  - Central Laboratory, Markusovszky Teaching Hospital, Szombathely, Hungary.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 3K9958V90M (Ethanol)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Animals
MH  - Atrial Natriuretic Factor/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/*toxicity
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Seizures/chemically induced/drug therapy
MH  - Substance Withdrawal Syndrome/*drug therapy
EDAT- 1993/07/20 00:00
MHDA- 1993/07/20 00:01
CRDT- 1993/07/20 00:00
PHST- 1993/07/20 00:00 [pubmed]
PHST- 1993/07/20 00:01 [medline]
PHST- 1993/07/20 00:00 [entrez]
AID - 0014-2999(93)90878-L [pii]
AID - 10.1016/0014-2999(93)90878-l [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1993 Jul 20;238(2-3):417-9. doi: 10.1016/0014-2999(93)90878-l.