PMID- 8407011
OWN - NLM
STAT- MEDLINE
DCOM- 19931104
LR  - 20190816
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 39
IP  - 1
DP  - 1993 Apr
TI  - Non-specific aortoarteritis: long-term follow-up on immunosuppressive therapy.
PG  - 79-84
AB  - Thirteen patients with non-specific aortoarteritis and endomyocardial biopsy 
      evidence of myocarditis were followed-up on immunosuppressive therapy comprising 
      of prednisolone and cyclophosphamide in addition to conventional treatment for 
      hypertension and/or congestive heart failure. Serial determinations of 
      erythrocyte sedimentation rate, chest roentgenogram, radionuclide ventriculogram 
      and hemodynamic study including endomyocardial biopsy were carried out at 12, 24 
      and 52 weeks of therapy. Arterial lesions were also assessed by digital 
      subtraction angiography at 0 and 52 weeks of immunosuppressive therapy. At the 
      end of a year of treatment all patients with congestive heart failure (10/13) 
      showed symptomatic improvement by at least one New York Heart Association (NYHA) 
      class. There was a significant fall in erythrocyte sedimentation rate (48 +/- 12 
      mm/1st h to 31 +/- 12 mm/1st h, P < 0.05), pulmonary artery pressure (32 +/- 14 
      mmHg to 20 +/- 9 mmHg, P < 0.05), left ventricular filling pressure (20 +/- 11 
      mmHg to 11 +/- 7 mmHg, P < 0.05) and increase in left ventricle ejection fraction 
      (39 +/- 16% to 51 +/- 14%, P < 0.05) associated with resolution of morphological 
      changes on endomyocardial biopsy. Arterial lesions remained static with neither 
      progression nor appearance of new lesions. No significant complications of 
      therapy were noticed in any patient. Our uncontrolled observations suggest that 
      immunosuppressive therapy is safe and results in clinical, hemodynamic and 
      myocardial morphological improvement in a subset of patients with non-specific 
      aortoarteritis and associated myocarditis.
FAU - Talwar, K K
AU  - Talwar KK
AD  - Department of Cardiology, All India Institute of Medical Sciences, Ansari Nager, 
      New Delhi.
FAU - Vasan, R S
AU  - Vasan RS
FAU - Sharma, S
AU  - Sharma S
FAU - Chopra, P
AU  - Chopra P
FAU - Shrivastava, S
AU  - Shrivastava S
FAU - Malhotra, A
AU  - Malhotra A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Angiography, Digital Subtraction
MH  - Aortitis/diagnostic imaging/*drug therapy/pathology
MH  - Aortography
MH  - Biopsy
MH  - Child
MH  - Cohort Studies
MH  - Cyclophosphamide/*administration & dosage/adverse effects
MH  - Drug Therapy, Combination
MH  - Endocardium/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/diagnostic imaging/drug therapy/pathology
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Male
MH  - Myocarditis/diagnostic imaging/drug therapy/pathology
MH  - Myocardium/pathology
MH  - Prednisolone/*administration & dosage/adverse effects
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 0167-5273(93)90299-V [pii]
AID - 10.1016/0167-5273(93)90299-v [doi]
PST - ppublish
SO  - Int J Cardiol. 1993 Apr;39(1):79-84. doi: 10.1016/0167-5273(93)90299-v.