PMID- 8412394
OWN - NLM
STAT- MEDLINE
DCOM- 19931103
LR  - 20190821
IS  - 0025-7079 (Print)
IS  - 0025-7079 (Linking)
VI  - 31
IP  - 10
DP  - 1993 Oct
TI  - Relationship between functional status and health-related quality-of-life after 
      myocardial infarction.
PG  - 950-5
AB  - Despite increasing use in clinical and economic studies, no gold standard exists 
      for the measurement of health-related quality of life (HRQL). One approach to 
      assessing the validity of an HRQL instrument for a particular disease population 
      is to examine the empirical relationship between HRQL patient scores and other 
      accepted measures of health or functional status. In 185 patients (mean age 60 
      years, 79% male) at six months after myocardial infarction, we examined the 
      relationship between patient responses to the Nottingham Health Profile (NHP), a 
      generic HRQL instrument, and physician classification of patients by two widely 
      used functional status indicators: the New York Heart Association (NYHA) 
      classification and the Karnofsky Performance Status Scale. Analysis of NHP scores 
      by NYHA strata confirms that lower HRQL is associated with poorer cardiac 
      functional status (P < 0.0001) and this gradient is observed over all six NHP 
      domains. Statistically significant (P < 0.001) associations were observed between 
      patients' NYHA class and NHP domain scores for energy (Spearman r = 0.52), 
      physical mobility (r = 0.45) and pain (r = 0.43). NHP scores for patients in NYHA 
      Class I were similar to male population controls. A similarly consistent 
      relationship was found between NHP and Karnofsky. We conclude that the NHP is 
      able to discriminate between patients with differing levels of cardiac 
      functioning as classified by NYHA and patient functioning as classified by 
      Karnofsky. Demonstration of such discriminative properties is one important 
      component in assessing the construct validity of HRQL measures.
FAU - O'Brien, B J
AU  - O'Brien BJ
AD  - Department of Clinical Epidemiology and Biostatistics, McMaster University, 
      Hamilton, Ontario, Canada.
FAU - Buxton, M J
AU  - Buxton MJ
FAU - Patterson, D L
AU  - Patterson DL
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Care
JT  - Medical care
JID - 0230027
SB  - IM
MH  - Activities of Daily Living
MH  - Analysis of Variance
MH  - Female
MH  - Follow-Up Studies
MH  - *Health Status Indicators
MH  - Humans
MH  - Karnofsky Performance Status
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*classification/epidemiology/*physiopathology
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Severity of Illness Index
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 10.1097/00005650-199310000-00006 [doi]
PST - ppublish
SO  - Med Care. 1993 Oct;31(10):950-5. doi: 10.1097/00005650-199310000-00006.