PMID- 8412753
OWN - NLM
STAT- MEDLINE
DCOM- 19931109
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 42
IP  - 10
DP  - 1993 Oct
TI  - Acute reduction of renal 11 beta-hydroxysteroid dehydrogenase activity by several 
      antinatriuretic stimuli.
PG  - 1370-4
AB  - The 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) activity of the kidney 
      prevents access of cortisol or corticosterone to the renal mineralocorticoid 
      receptor. Reduction of 11 beta-HSD activity by nutritional, hormonal, or 
      pharmacologic factors might enhance the mineralocorticoid effect of these 
      corticosteroids, thus causing sodium retention. To test this concept, we studied 
      the effect on 11 beta-HSD activity of several antinatriuretic factors given 
      orally to rats or exposed in vitro to rat renal tissue. Renal 11 beta-HSD 
      activity was higher in fasted than fed rats (P < .05). Glucose, ethanol, and 
      Toradol (Syntex Laboratories, Palo Alto, CA) given orally to fasted rats all 
      reduced renal 11 beta-HSD activity by 20% to 40% (P < .05-.005) to levels similar 
      to those observed in fed animals. Incubation of renal tissue from fasted rats 
      with physiologic concentrations of insulin, ethanol, and Toradol also reduced 11 
      beta-HSD activity by 20% to 40% (P < .05-.01). These findings are consistent with 
      the hypothesis that the antinatriuretic actions of these stimuli are due in part 
      to alteration of renal 11 beta-HSD leading to greater mineralocorticoid effects 
      in kidney.
FAU - Riddle, M C
AU  - Riddle MC
AD  - Department of Medicine, Oregon Health Sciences University, Portland 97201-3098.
FAU - McDaniel, P A
AU  - McDaniel PA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Drug Combinations)
RN  - 0 (Insulin)
RN  - 023C2WHX2V (Tromethamine)
RN  - 3K9958V90M (Ethanol)
RN  - 4EVE5946BQ (Ketorolac Tromethamine)
RN  - D8K2JPN18B (Tolmetin)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
RN  - IY9XDZ35W2 (Glucose)
RN  - W980KJ009P (Corticosterone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Administration, Oral
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*pharmacology
MH  - Corticosterone/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Combinations
MH  - Eating/physiology
MH  - Ethanol/administration & dosage/*pharmacology
MH  - Fasting/metabolism/physiology
MH  - Glucose/administration & dosage/*pharmacology
MH  - Hydrocortisone/metabolism
MH  - Hydroxysteroid Dehydrogenases/*analysis/metabolism/physiology
MH  - Insulin/pharmacology
MH  - Ketorolac Tromethamine
MH  - Kidney/*enzymology
MH  - Male
MH  - Natriuresis/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tolmetin/administration & dosage/*analogs & derivatives/pharmacology
MH  - Tromethamine/administration & dosage/*pharmacology
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 0026-0495(93)90140-J [pii]
AID - 10.1016/0026-0495(93)90140-j [doi]
PST - ppublish
SO  - Metabolism. 1993 Oct;42(10):1370-4. doi: 10.1016/0026-0495(93)90140-j.