PMID- 8412776
OWN - NLM
STAT- MEDLINE
DCOM- 19931101
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 42
IP  - 9
DP  - 1993 Sep
TI  - Energy metabolism in response to overfeeding in young adult men.
PG  - 1201-5
AB  - The effect of overfeeding on energy metabolism was evaluated in four young adult 
      men of normal weight. Subjects were fed a hypocaloric diet for 8 days followed by 
      an 8-day hypercaloric diet to maximize differences in the metabolic response to 
      the two diets. Energy intake during the hypocaloric and hypercaloric phases was 
      1.32 and 2.26 times resting metabolic rate (RMR), respectively. Additional 
      calories during hypercaloric feeding were provided as 1,659 +/- 40 kcal/d 
      carbohydrate and lipid. Total daily energy expenditure (TDEE) was measured by the 
      doubly labeled water technique and RMR by indirect calorimetry. Nonresting energy 
      expenditure (NREE) was calculated as the difference between TDEE and RMR. During 
      the 8-day hypocaloric diet period, energy intake was approximately 340 kcal/d 
      less than the measured rate of TDEE (2,384 +/- 219 kcal/d) and the subjects lost 
      0.8 +/- 0.3 kg body weight. During the 8-day hypercaloric diet period, TDEE 
      increased by 425 +/- 103 kcal/d (P = .03), which dissipated 25% +/- 5% of the 
      increased energy intake. One fourth of the increase in TDEE was caused by an 
      increase in RMR (110 +/- 24 kcal/d, P = .02) and the remainder by an increase in 
      NREE (316 +/- 103 kcal/d, P = .05). These results demonstrate that only a small 
      portion of excess energy intake is dissipated by an increase in energy 
      expenditure. NREE can be an important component of the increase in energy 
      metabolism during overfeeding.
FAU - Klein, S
AU  - Klein S
AD  - Department of Internal Medicine, University of Texas Medical Branch, Galveston.
FAU - Goran, M
AU  - Goran M
LA  - eng
GR  - CA50330/CA/NCI NIH HHS/United States
GR  - MO1RR0073/RR/NCRR NIH HHS/United States
GR  - MO1RR109/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
SB  - IM
MH  - Adult
MH  - Energy Intake
MH  - *Energy Metabolism
MH  - Humans
MH  - Hyperphagia/*metabolism
MH  - Male
MH  - Rest
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 0026-0495(93)90281-R [pii]
AID - 10.1016/0026-0495(93)90281-r [doi]
PST - ppublish
SO  - Metabolism. 1993 Sep;42(9):1201-5. doi: 10.1016/0026-0495(93)90281-r.