PMID- 8413831
OWN - NLM
STAT- MEDLINE
DCOM- 19931117
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 57
IP  - 5
DP  - 1993 May
TI  - Serotonin, catecholamines and metabolites in discrete brain areas in relation to 
      lordotic responding on proestrus.
PG  - 946-54
AB  - Levels of serotonin (5-HT) and metabolite, 5-hydroxyindole-acetic acid (5-HIAA), 
      dopamine and metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic 
      acid (HVA), and norepinephrine (NE) were measured in microdissected brain areas 
      at 14.30 and 19.30 h on diestrus and proestrus in rats. Lordosis, sexual 
      behavior, was exhibited only by proestrous females at 19.30 h. The content of 
      monoamines and/or metabolites changed from afternoon to early evening of diestrus 
      in a number of brain regions. On proestrus, during the time when females became 
      sexually receptive, additional changes appeared and many diestrous changes were 
      reversed or amplified. Proestrus-specific changes were found in areas providing 
      the descending circuit for regulation of lordosis, the medial preoptic nucleus 
      (mPOA), ventromedial nucleus of the hypothalamus (VMN) and midbrain central gray 
      (MCG), and in areas outside of endocrine control centers such as parietal cortex 
      (Ctx) and dorsal raphe nucleus (DR). Thus, these data are consistent with 
      previous studies showing functional changes in monoaminergic transmitters during 
      the day/night cycle and during hormonal induction of neuroendocrine events. NE 
      levels increased between 14.30 and 19.30 h on proestrus in most brain areas, 
      ranging from 20% increases in mPOA and Ctx to a 220% increase in the DR. NE 
      levels decreased on proestrus in the VMN. The direction of proestrous changes in 
      NE were reversed in some, but not all of the areas, between the afternoon and 
      evening of diestrus. Dopamine was detectable in all areas sampled, and the 
      metabolites HVA and DOPAC were detectable in some but not all areas.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Luine, V N
AU  - Luine VN
AD  - Department of Psychology, Hunter College of CUNY, New York 10021.
LA  - eng
GR  - HD 12011/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Catecholamines)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Catecholamines/*metabolism
MH  - Female
MH  - Periaqueductal Gray/metabolism
MH  - Preoptic Area/metabolism
MH  - *Proestrus
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Sexual Behavior, Animal/*physiology
MH  - Tissue Distribution
MH  - Ventromedial Hypothalamic Nucleus/metabolism
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
AID - 10.1159/000126458 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1993 May;57(5):946-54. doi: 10.1159/000126458.