PMID- 8415411
OWN - NLM
STAT- MEDLINE
DCOM- 19931118
LR  - 20190818
IS  - 0724-8741 (Print)
IS  - 0724-8741 (Linking)
VI  - 10
IP  - 8
DP  - 1993 Aug
TI  - Dissolution, stability, and morphological properties of conventional and 
      multiphase poly(DL-lactic-co-glycolic acid) microspheres containing water-soluble 
      compounds.
PG  - 1219-27
AB  - Multiphase microspheres of poly(DL-lactic-co-glycolic acid) (PLGA) containing 
      water-soluble compounds were prepared by a multiple-emulsion solvent evaporation 
      technique. These compounds were dissolved in the aqueous phase of a W/O emulsion 
      with soybean oil as the oil phase. This emulsion was dispersed throughout the 
      matrix of the microsphere. The morphological properties of the multiphase 
      microspheres during in vitro dissolution studies were compared to those of 
      conventional microspheres prepared from the same polymer. Drug release from the 
      multiphase microspheres was characterized by an initial uniform release for the 
      first 20 days followed by a more rapid phase of drug release. Chlorpheniramine 
      maleate (CPM) and brilliant blue (BB) were the soluble model compounds 
      investigated. The release rates of these agents from the multiphase microspheres 
      were independent of the drug content in the microspheres. The release profiles 
      from the conventional microspheres showed a lag time of 10 and 16 days for the 
      CPM and BB, respectively. The dissolution rate of the model soluble compounds 
      from the conventional microspheres increased as the loading in the microspheres 
      increased. No differences in the degradation rate of the PLGA from the multiphase 
      and the conventional microspheres were seen during the dissolution studies.
FAU - Iwata, M
AU  - Iwata M
AD  - College of Pharmacy, University of Texas, Austin 78712-1074.
FAU - McGinity, J W
AU  - McGinity JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharm Res
JT  - Pharmaceutical research
JID - 8406521
RN  - 0 (Acetonitriles)
RN  - 0 (Benzenesulfonates)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 3U6IO1965U (Chlorpheniramine)
RN  - 8020-83-5 (Mineral Oil)
RN  - H3R47K3TBD (brilliant blue)
SB  - IM
MH  - Acetonitriles
MH  - Benzenesulfonates/chemistry
MH  - Chlorpheniramine/chemistry
MH  - Chromatography, Gel
MH  - Drug Stability
MH  - *Lactic Acid
MH  - Microscopy, Electron, Scanning
MH  - Microspheres
MH  - Mineral Oil
MH  - Molecular Weight
MH  - Particle Size
MH  - *Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - Solubility
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 10.1023/a:1018984722208 [doi]
PST - ppublish
SO  - Pharm Res. 1993 Aug;10(8):1219-27. doi: 10.1023/a:1018984722208.