PMID- 8415805
OWN - NLM
STAT- MEDLINE
DCOM- 19931123
LR  - 20190914
IS  - 0952-3278 (Print)
IS  - 0952-3278 (Linking)
VI  - 49
IP  - 2
DP  - 1993 Aug
TI  - Dietary fish oil supplementation alters LTB4:LTB5 ratios but does not affect the 
      expression of acute graft versus host disease in mice.
PG  - 561-8
AB  - One of the mechanisms by which corticosteroids may modify acute graft vs host 
      disease (GvHD) is via inhibition of arachidonic acid (AA) metabolism. Leukotriene 
      B4 (LTB4) is a product of that pathway which may take part in the pathogenesis of 
      GvHD through the stimulation of T-lymphopoiesis and T-lymphocyte activation. LTB4 
      is a metabolite of AA (20:4n-6). Alternate dietary sources of polyunsaturated 
      fatty acids (PUFA), specifically eicosapenteinoic acid (20:5n-3) (EPA) and 
      docosahexaenoic acid (22:6n-3) (DHA), shift the LTs formed with a decrease in 
      LTB4 an increase in LTB5. LTB5 is a less potent agonist than LTB4 and this 
      results in a theoretical decrease of LTB4 mediated events. Supplementation of in 
      vitro bone marrow cultures with EPA or DHA had no detrimental effect on myeloid 
      colony formation. Dietary EPA/DHA supplementation in mice with induced GvHD 
      appeared to be safe and well tolerated. The LTB4:LTB5 ratio shifted from 7.65 +/- 
      1.75 in control-fed animals to 1.03 +/- 0.18. Fish-oil-supplementation did not 
      compromise engraftment or stem cell content. Alone, this therapy was unable to 
      modify GvHD.
FAU - Miller, A M
AU  - Miller AM
AD  - Division of Medical Oncology, College of Medicine, University of Florida, 
      Gainesville 32610-0277.
FAU - van Bekkum, D W
AU  - van Bekkum DW
FAU - Kobb, S M
AU  - Kobb SM
FAU - McCrohan, M B
AU  - McCrohan MB
FAU - Knaan-Shanzer, S
AU  - Knaan-Shanzer S
LA  - eng
PT  - Journal Article
PL  - Scotland
TA  - Prostaglandins Leukot Essent Fatty Acids
JT  - Prostaglandins, leukotrienes, and essential fatty acids
JID - 8802730
RN  - 0 (Fish Oils)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
RN  - EC 1.13.11.12 (Lipoxygenase)
SB  - IM
MH  - Animals
MH  - Arachidonic Acid/pharmacology
MH  - Bone Marrow/drug effects
MH  - Disease Models, Animal
MH  - Docosahexaenoic Acids/pharmacology
MH  - Eicosapentaenoic Acid/pharmacology
MH  - Fish Oils/*pharmacology/therapeutic use
MH  - Graft vs Host Disease/*diet therapy/*immunology/metabolism
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/drug effects
MH  - Humans
MH  - In Vitro Techniques
MH  - Leukotriene B4/*metabolism
MH  - Lipoxygenase/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Spleen/drug effects
MH  - T-Lymphocytes/drug effects
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 10.1016/0952-3278(93)90161-o [doi]
PST - ppublish
SO  - Prostaglandins Leukot Essent Fatty Acids. 1993 Aug;49(2):561-8. doi: 
      10.1016/0952-3278(93)90161-o.