PMID- 8418115
OWN - NLM
STAT- MEDLINE
DCOM- 19930204
LR  - 20190709
IS  - 0002-8614 (Print)
IS  - 0002-8614 (Linking)
VI  - 41
IP  - 1
DP  - 1993 Jan
TI  - Influenza A virus-specific cytotoxic T lymphocyte activity declines with 
      advancing age.
PG  - 1-5
AB  - OBJECTIVE: To investigate whether influenza A-specific cytotoxic T lymphocyte 
      (CTL) activity is reduced in elderly compared with younger adults. DESIGN: Case 
      series comparing outcomes in young and elderly cohorts. SETTING: Saint Louis 
      University Division of Geriatric Medicine. PARTICIPANTS: Healthy adult 
      outpatients and staff members aged < 50 (young) or > or = 65 (elderly) years. 
      METHODS: Peripheral blood mononuclear cells were assayed for CTL activity by a 
      51chromium release assay following 1 week of in vitro stimulation with influenza 
      A/PR/8/34 (H1N1) virus. MEASUREMENTS: Percent specific lysis of autologous and 
      allogeneic influenza virus-infected target cells. MAIN RESULTS: Specific lysis of 
      autologous A/PR-infected targets was significantly lower in elderly compared to 
      young subjects (P < 0.01), and exceeded 10% in a significantly lower proportion 
      of elderly compared with younger subjects (P < 0.05), but was not influenced by a 
      history of vaccination within the preceding 12 months. Cytotoxic effectors were 
      class I human leukocyte antigen (HLA)-restricted and displayed heterosubtypic 
      cross-reactivity but were unable to lyse influenza B-infected targets. 
      CONCLUSIONS: These results demonstrate an age-related decline of influenza A 
      virus-specific CTL activity and suggest that CTL responses to inactivated virus 
      vaccine are of short duration.
FAU - Powers, D C
AU  - Powers DC
AD  - Geriatric Research, Education and Clinical Center, St. Louis VAMC, Missouri.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
CIN - J Am Geriatr Soc. 1993 Aug;41(8):887. PMID: 8340570
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*immunology
MH  - Biological Assay
MH  - Cross Reactions
MH  - Cytotoxicity Tests, Immunologic
MH  - Cytotoxicity, Immunologic/*immunology
MH  - Evaluation Studies as Topic
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunologic Memory/immunology
MH  - Influenza A virus/classification/*immunology
MH  - Influenza B virus/immunology
MH  - Middle Aged
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1111/j.1532-5415.1993.tb05938.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 1993 Jan;41(1):1-5. doi: 10.1111/j.1532-5415.1993.tb05938.x.