PMID- 8421182
OWN - NLM
STAT- MEDLINE
DCOM- 19930212
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 167
IP  - 2
DP  - 1993 Feb
TI  - Endotoxin and tumor necrosis factor-alpha-induced interleukin-8 release in 
      humans.
PG  - 461-54
AB  - Neutrophil recruitment and activation are thought to play an important role in 
      tissue damage observed in septicemia. Interleukin-8 (IL-8) is a small cytokine 
      with important neutrophil-activating and chemoattractant properties. IL-8 release 
      was studied after injection of human volunteers with low doses of either 
      endotoxin (2 ng/kg of body weight) or tumor necrosis factor-alpha (TNF alpha) (50 
      micrograms/m2). After TNF-alpha injection, IL-8 appeared at 30 min, whereas 
      increased levels were first observed after 90 min in endotoxin-challenged 
      volunteers. Peak levels were measured at 120 min after both endotoxin (192 +/- 
      193 ng/L) and TNF alpha (500 +/- 236 ng/L) injection. These data indicate that 
      IL-8 is released in humans after injection of endotoxin and TNF alpha and suggest 
      that endotoxin-induced IL-8 release is mediated by TNF alpha.
FAU - van Deventer, S J
AU  - van Deventer SJ
AD  - Department of Internal Medicine, University of Amsterdam, Netherlands.
FAU - Hart, M
AU  - Hart M
FAU - van der Poll, T
AU  - van der Poll T
FAU - Hack, C E
AU  - Hack CE
FAU - Aarden, L A
AU  - Aarden LA
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Endotoxins)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 67924-63-4 (endotoxin, Escherichia coli)
SB  - IM
MH  - Adult
MH  - Endotoxins/administration & dosage/*pharmacology
MH  - *Escherichia coli
MH  - Humans
MH  - Injections, Intravenous
MH  - Interleukin-8/*metabolism
MH  - Tumor Necrosis Factor-alpha/administration & dosage/*pharmacology
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1093/infdis/167.2.461 [doi]
PST - ppublish
SO  - J Infect Dis. 1993 Feb;167(2):461-54. doi: 10.1093/infdis/167.2.461.