PMID- 8424384
OWN - NLM
STAT- MEDLINE
DCOM- 19930225
LR  - 20180330
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 57
IP  - 2
DP  - 1993 Feb
TI  - An isotopic study of the effect of dietary carbohydrate on the metabolic fate of 
      dietary leucine and phenylalanine.
PG  - 161-9
AB  - The fate of dietary leucine and phenylalanine was studied in five healthy, young 
      adult men, by using a dual, stable isotope-tracer infusion approach to estimate 
      amino acid fluxes, splanchnic (Sp) uptake, and dietary of absorbed amino acid to 
      the peripheral circulation. Subject received two, 4-h tracer infusions of 
      [1-13C]leucine and [15N]phenylalanine infused through a feeding tube placed in 
      the duodenum, and [5,5,5-2H3]leucine, [ring-2H5]phenylalanine, and 
      [6,6-2H2]glucose infused simultaneously by vein. In one experiment subjects 
      received an amino acid mixture (83 mg amino acid.kg-1.h-1) via the feeding tube 
      and in the other experiment amino acids were supplied with carbohydrate (CHO) 
      (167 mg.kg-1.h-1). Sp uptake of dietary leucine decreased with added dietary CHO 
      (29% of ingested leucine for amino acids alone vs 20% with CHO; P < 0.05) but was 
      not different for phenylalanine (P > 0.05). Addition of CHO decreased both 
      release of leucine via protein breakdown and leucine oxidation and increased body 
      leucine balance (P < 0.05).
FAU - Krempf, M
AU  - Krempf M
AD  - Clinical Research Center and School of Science, Massachusetts Institute of 
      Technology, Cambridge 02142.
FAU - Hoerr, R A
AU  - Hoerr RA
FAU - Pelletier, V A
AU  - Pelletier VA
FAU - Marks, L M
AU  - Marks LM
FAU - Gleason, R
AU  - Gleason R
FAU - Young, V R
AU  - Young VR
LA  - eng
GR  - DK 15856/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Blood Glucose)
RN  - 0 (Carbon Isotopes)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Keto Acids)
RN  - 0 (Nitrogen Isotopes)
RN  - 47E5O17Y3R (Phenylalanine)
RN  - 816-66-0 (alpha-ketoisocaproic acid)
RN  - AR09D82C7G (Deuterium)
RN  - GMW67QNF9C (Leucine)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Carbon Isotopes
MH  - Deuterium
MH  - *Diet
MH  - Dietary Carbohydrates/*pharmacology
MH  - Humans
MH  - Keto Acids/metabolism
MH  - Leucine/administration & dosage/blood/*pharmacokinetics
MH  - Male
MH  - Nitrogen Isotopes
MH  - Oxidation-Reduction
MH  - Phenylalanine/administration & dosage/blood/*pharmacokinetics
MH  - Splanchnic Circulation
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1093/ajcn/57.2.161 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 1993 Feb;57(2):161-9. doi: 10.1093/ajcn/57.2.161.