PMID- 842491
OWN - NLM
STAT- MEDLINE
DCOM- 19770430
LR  - 20180330
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 30
IP  - 3
DP  - 1977 Mar
TI  - Effect of carbohydrate restriction and high carbohydrates diets on men with 
      chemical diabetes.
PG  - 402-8
AB  - The influence of low carbohydrate (CHO) diets, starvation, and high CHO diets on 
      glucose tolerance tests (GTT) and plasma insulin response of men with chemical 
      diabetes was studied. The GTT and insulin responses of these seven lean diabetic 
      men were unchanged when the carbohydrate content of the diet was reduced from 44 
      to 20% of calories. After a 48-hr fast a significant deterioration of the GTT was 
      observed in these diabetic men but the percentage change was identical to that 
      reported previously for normal men. Thus these studies indicate that changes in 
      glucose mtes are quite similar to those reported previously for normal men. The 
      fasting plasma glucose values of seven lean and four obese men with chemical 
      diabetes were significantly lower after one week on a 75% CHO diet than values on 
      a 44% CHO diet. The 75% CHO diet also was accompanied by slight improvements in 
      the oral and intravenous GTT and by slightly lower plasma insulin responses. The 
      improvement in glucose metabolism on high CHO diets appears to results from 
      increased insulin sensitivity. Serum triglyceride values were approximately 55% 
      higher on the 75% CHO diet than values on the 44% CHO diet for the 11 men but 
      these differences were not statistically significant. These studies support 
      previous observations and suggest that high CHO diets may be beneficial in the 
      management of certain diabetic patients. However, further studies are required to 
      determine the long-term effects of high CHO diets containing natural foods on the 
      glucose and lipid metabolism of diabetic patients.
FAU - Anderson, J W
AU  - Anderson JW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus/*metabolism
MH  - *Dietary Carbohydrates
MH  - Glucose/*metabolism
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - *Obesity
MH  - Prediabetic State/*metabolism
MH  - Starvation
MH  - Triglycerides/blood
EDAT- 1977/03/01 00:00
MHDA- 1977/03/01 00:01
CRDT- 1977/03/01 00:00
PHST- 1977/03/01 00:00 [pubmed]
PHST- 1977/03/01 00:01 [medline]
PHST- 1977/03/01 00:00 [entrez]
AID - 10.1093/ajcn/30.3.402 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 1977 Mar;30(3):402-8. doi: 10.1093/ajcn/30.3.402.