PMID- 8427663
OWN - NLM
STAT- MEDLINE
DCOM- 19930309
LR  - 20190512
IS  - 0895-7061 (Print)
IS  - 0895-7061 (Linking)
VI  - 6
IP  - 1
DP  - 1993 Jan
TI  - Effect of intravenous calcium infusion on indices of activity of the parathyroid 
      glands and on urinary calcium and sodium excretion in normotensive and 
      hypertensive subjects.
PG  - 59-65
AB  - The effect of an intravenous calcium gluconate load (10 mg/kg over 5 min) on 
      plasma ionized calcium concentration, parathyroid hormone (PTH), and the rate of 
      urinary excretion of calcium, sodium, and nephrogenous cyclic adenosine 
      monophosphate (NcAMP) was examined in 26 patients with essential hypertension and 
      27 age- and sex-matched normotensive subjects. Prior to calcium administration 
      hypertensives had lower plasma ionized calcium concentration (P < .01) and higher 
      PTH levels (P < .001) and excreted more calcium (P < .05) and NcAMP (P < .001) in 
      the urine compared to normotensives. Following calcium infusion, plasma ionized 
      calcium did not differ significantly between the two groups, but PTH levels 
      remained higher in the hypertensive subjects at both 60 min (P < .001), and at 
      120 min (P = .02) post-load. Post-load values for both urinary calcium excretion 
      and urinary sodium excretion were significantly higher in the hypertensive 
      subjects than in the control group. Both before and after calcium infusion, 
      urinary calcium excretion was positively correlated with urinary sodium excretion 
      in each of the two groups, but for the same level of sodium excretion, 
      hypertensives excreted more calcium in the urine, compared to normotensives, both 
      before (P < .05) and after calcium infusion (P < .001). A positive correlation 
      between basal plasma renin activity (PRA) values and plasma ionized calcium 
      values obtained before (r = 0.42, P = .03) or at 60 min (r = 0.41, P = .03) and 
      120 min (r = 0.42, P = .03) after calcium infusion existed only in the 
      hypertensive subject group. Post-load urinary sodium excretion values were 
      negatively correlated to basal PRA values in both groups (r = -0.55, P < .01 and 
      r = -0.58, P < .01 for hypertensives and normotensives, respectively), but a 
      similar negative correlation between post-load urinary calcium excretion values 
      and basal PRA values existed only in the hypertensive subject group (r = -0.50, P 
      < .01).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Papagalanis, N
AU  - Papagalanis N
AD  - Nephrology Department Red Cross General Hospital, Athens, Greece.
FAU - Kourti, A
AU  - Kourti A
FAU - Tolis, A
AU  - Tolis A
FAU - Skopelitis, P
AU  - Skopelitis P
FAU - Karabatsos, A
AU  - Karabatsos A
FAU - Kostoyanni, G
AU  - Kostoyanni G
FAU - Gennadiou, M
AU  - Gennadiou M
FAU - Elisaf, M
AU  - Elisaf M
FAU - Mountokalakis, T
AU  - Mountokalakis T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (Parathyroid Hormone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Calcium/*pharmacology/*urine
MH  - Female
MH  - Humans
MH  - Hypertension/blood/*physiopathology/urine
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Natriuresis/*drug effects
MH  - Osmolar Concentration
MH  - Parathyroid Glands/*drug effects/physiopathology
MH  - Parathyroid Hormone/blood
MH  - Reference Values
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 0895-7061(93)90156-G [pii]
AID - 10.1093/ajh/6.1.59 [doi]
PST - ppublish
SO  - Am J Hypertens. 1993 Jan;6(1):59-65. doi: 10.1093/ajh/6.1.59.