PMID- 8428243
OWN - NLM
STAT- MEDLINE
DCOM- 19930309
LR  - 20190830
IS  - 0263-7103 (Print)
IS  - 0263-7103 (Linking)
VI  - 32
IP  - 2
DP  - 1993 Feb
TI  - Differentiating persistent from self-limiting symmetrical synovitis in an early 
      arthritis clinic.
PG  - 97-103
AB  - Early rheumatoid arthritis (RA) must be differentiated from benign self-limiting 
      polyarthritis because of the risks associated with treatment of RA. Conventional, 
      widely available clinical and laboratory variables, measured at first clinic 
      visit, were studied for their ability to predict persistence in 112 patients with 
      up to 6 months of joint symptoms. Those 65 patients with symmetrical peripheral 
      polyarthritis were followed for 1 year: 36 who underwent spontaneous remission 
      were classified self-limiting synovitis (SLS); the remaining 29 were termed 
      persistent synovitis (PS). Univariate analysis suggested more severe disease in 
      PS at presentation but showing considerable overlap with SLS, making clinical 
      discrimination difficult. Multivariate analysis confirmed this overlap but 
      identified a subset of most helpful variables. The RA latex was the most powerful 
      variable, yet accounted for only 45% of the variability in outcome. Combining a 
      positive RA latex with an ESR > 30 mm/h carried a relative risk for PS of 4.33, 
      with specificity 94% but sensitivity only 69%. Self-limiting synovitis initially 
      could not be distinguished from early RA: hence RA may exist in two forms, the 
      traditional persistent form and a less well recognized abortive form.
FAU - Tunn, E J
AU  - Tunn EJ
AD  - Department of Rheumatology, University of Birmingham.
FAU - Bacon, P A
AU  - Bacon PA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Rheumatol
JT  - British journal of rheumatology
JID - 8302415
SB  - IM
CIN - Br J Rheumatol. 1993 Aug;32(8):764. PMID: 8348286
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthritis/classification/*diagnosis/physiopathology
MH  - Clinical Protocols
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Joints/pathology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Remission, Spontaneous
MH  - Synovitis/classification/*diagnosis/physiopathology
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1093/rheumatology/32.2.97 [doi]
PST - ppublish
SO  - Br J Rheumatol. 1993 Feb;32(2):97-103. doi: 10.1093/rheumatology/32.2.97.