PMID- 8429321
OWN - NLM
STAT- MEDLINE
DCOM- 19930310
LR  - 20220311
IS  - 0022-3050 (Print)
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 56
IP  - 1
DP  - 1993 Jan
TI  - Intravenous immunoglobulin treatment in patients with chronic inflammatory 
      demyelinating polyneuropathy: a double blind, placebo controlled study.
PG  - 36-9
AB  - Patients with a clinical diagnosis of chronic inflammatory demyelinating 
      polyneuropathy (CIDP) were randomised in a double-blind, placebo-controlled 
      multicentre trial to investigate whether high-dose intravenous immunoglobulin 
      treatment (IVIg) for 5 consecutive days has a beneficial effect. Fifteen patients 
      were randomised to IVIg and 13 to placebo. In the IVIg treatment group 4 patients 
      improved and 3 patients in the placebo group. The degree of improvement of the 
      patients in the IVIg treatment group was no different from the patients in the 
      placebo group. Electrophysiological studies did not show significant differences 
      between the groups. Since a previously performed cross-over trial showed that a 
      selected group of CIDP patients responded better to IVIg than to placebo, it is 
      concluded that we need better criteria to select CIDP patients for treatment with 
      IVIg.
FAU - Vermeulen, M
AU  - Vermeulen M
AD  - Department of Neurology, University of Amsterdam, The Netherlands.
FAU - van Doorn, P A
AU  - van Doorn PA
FAU - Brand, A
AU  - Brand A
FAU - Strengers, P F
AU  - Strengers PF
FAU - Jennekens, F G
AU  - Jennekens FG
FAU - Busch, H F
AU  - Busch HF
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Placebos)
SB  - IM
MH  - Chronic Disease
MH  - Demyelinating Diseases/*drug therapy/immunology
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Placebos
MH  - Treatment Outcome
PMC - PMC1014761
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
PMCR- 1993/01/01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
PHST- 1993/01/01 00:00 [pmc-release]
AID - 10.1136/jnnp.56.1.36 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 1993 Jan;56(1):36-9. doi: 10.1136/jnnp.56.1.36.