PMID- 8429642
OWN - NLM
STAT- MEDLINE
DCOM- 19930311
LR  - 20190817
IS  - 0022-4804 (Print)
IS  - 0022-4804 (Linking)
VI  - 54
IP  - 1
DP  - 1993 Jan
TI  - The role of the adrenals in the acute phase response to interleukin-1 and tumor 
      necrosis factor-alpha.
PG  - 70-8
AB  - The purpose of this study was to investigate the role of the adrenals, 
      particularly the glucocorticoids, in the acute phase response following daily 
      injections for 5 days of recombinant human interleukin-1 alpha,beta and tumor 
      necrosis factor-alpha (TNF alpha). Adult weight-stable freely fed or pair-fed (to 
      cytokine-injected mice) mice (C57Bl/6J) with and without adrenals were used. 
      Adrenalectomized animals showed a sensitivity to both IL-1 alpha and -1 beta (40 
      ng IL-1/day) greater than 10-fold higher than that of normal mice (420 ng 
      IL-1/day) in regard to mortality and anorexia. Microscopic examination of tissue 
      specimens from adrenalectomized IL-1 alpha,beta-injected mice did not reveal any 
      histologic alterations in lung, kidney, liver, brain, or gastrointestinal tract 
      to explain the mortality. This mortality was not prevented by physiologic 
      replacement doses of hydrocortisone (10-20 micrograms/day); however, a 
      pharmacological dose of 2.5 mg hydrocortisone/day abolished completely the 
      increased toxicity to IL-1 alpha,beta and the anorectic response to IL-1 
      alpha,beta and TNF alpha. Increased toxicity (mortality) was not observed in 
      adrenalectomized animals with TNF alpha at the dose interval used (450 ng TNF 
      alpha/day and lower). The hepatic acute phase response (liver weight and RNA and 
      liver protein content) was increased by both IL-1 alpha,beta and TNF alpha in a 
      glucocorticoid-independent way. The cytokine-induced alterations of plasma 
      concentrations of acute phase proteins (serum amyloid P, transferrin, complement 
      C3) were significantly dependent on glucocorticoids, while the decline in plasma 
      albumin was not.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Gelin, J L
AU  - Gelin JL
AD  - Department of Surgery, University of Gothenburg, Sahlgrenska Hospital, Sweden.
FAU - Moldawer, L L
AU  - Moldawer LL
FAU - Iresjo, B M
AU  - Iresjo BM
FAU - Lundholm, K G
AU  - Lundholm KG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Glucocorticoids)
RN  - 0 (Interleukin-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acute-Phase Reaction/chemically induced/*physiopathology
MH  - Adrenal Glands/*physiopathology
MH  - Adrenalectomy
MH  - Animals
MH  - Anorexia/chemically induced
MH  - Body Weight
MH  - Dose-Response Relationship, Drug
MH  - Eating
MH  - Female
MH  - Glucocorticoids/*physiology
MH  - *Interleukin-1/administration & dosage/pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Tumor Necrosis Factor-alpha/administration & dosage/pharmacology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - S0022480483710127 [pii]
AID - 10.1006/jsre.1993.1012 [doi]
PST - ppublish
SO  - J Surg Res. 1993 Jan;54(1):70-8. doi: 10.1006/jsre.1993.1012.