PMID- 8430969
OWN - NLM
STAT- MEDLINE
DCOM- 19930309
LR  - 20061115
IS  - 0003-0805 (Print)
IS  - 0003-0805 (Linking)
VI  - 147
IP  - 2
DP  - 1993 Feb
TI  - Respiratory control during exercise in patients with cardiovascular disease.
PG  - 425-9
AB  - The pathophysiologic mechanism for exertional dyspnea, the main symptom of 
      patients with heart failure, has not been fully clarified. To determine the 
      relationship between exercise hyperpnea and the lactic acidosis in patients with 
      heart failure, we evaluated ventilation during incremental exercise both below 
      and above the lactic acidosis threshold in 16 normal subjects and in 48 patients 
      with cardiovascular disease while expired gas was analyzed continuously. The peak 
      oxygen uptake and oxygen uptake at the lactic acidosis threshold decreased 
      significantly as the New York Heart Association (NYHA) functional class severity 
      increased. the slope of the increase in ventilation to the increase in oxygen 
      uptake (delta VE/delta VO2) at work rates below the lactic acidosis threshold did 
      not differ between normal subjects and patients with heart failure. Above the 
      lactic acidosis threshold, however, the slope of delta VE/delta VO2, which was 
      higher than that below the lactic acidosis threshold in each of four groups, was 
      steeper in patients in NYHA Class II (60.8 +/- 17.9) and Class III (66.5 +/- 
      21.2) when compared with that in the normal subjects (46.6 +/- 13.5) or the 
      patients in NYHA Class I (46.1 +/- 10.3). The lactic acidosis caused by decreased 
      oxygen transport to working muscles accounts for the higher ventilation during 
      exercise in cardiac patients. These data suggest that the increased ventilation 
      during exercise, which must be related to exertional dyspnea, in patients with 
      cardiovascular disease is primarily the consequence of a stimulus to regulate 
      arterial pH.
FAU - Koike, A
AU  - Koike A
AD  - Second Department of Internal Medicine, Tokyo Medical and Dental University, 
      Japan.
FAU - Hiroe, M
AU  - Hiroe M
FAU - Taniguchi, K
AU  - Taniguchi K
FAU - Marumo, F
AU  - Marumo F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am Rev Respir Dis
JT  - The American review of respiratory disease
JID - 0370523
SB  - IM
CIN - Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):1146-7. PMID: 8214935
MH  - Acidosis, Lactic/epidemiology/physiopathology
MH  - Aged
MH  - Analysis of Variance
MH  - Breath Tests
MH  - Cardiovascular Diseases/epidemiology/*physiopathology
MH  - Exercise/*physiology
MH  - Exercise Test/instrumentation/methods/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/physiology
MH  - Respiration/*physiology
MH  - Respiratory Mechanics/physiology
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1164/ajrccm/147.2.425 [doi]
PST - ppublish
SO  - Am Rev Respir Dis. 1993 Feb;147(2):425-9. doi: 10.1164/ajrccm/147.2.425.