PMID- 8431850
OWN - NLM
STAT- MEDLINE
DCOM- 19930312
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 71
IP  - 3
DP  - 1993 Feb 1
TI  - Primary T-cell lymphoma of the gastrointestinal tract associated with human 
      T-cell lymphotropic virus type I. An analysis using in situ hybridization and 
      polymerase chain reaction.
PG  - 708-16
AB  - BACKGROUND: During a population-based local cancer registry, a peculiar type of 
      T-cell lymphoma restricted to the gastrointestinal tract was found in patients 
      living in southwestern Japan. METHODS: Five cases of gastrointestinal (GI) tract 
      T-cell lymphoma were analyzed with immunohistologic examination, ultrastructural 
      analysis, in situ hybridization (ISH), and polymerase chain reaction (PCR). 
      RESULTS: All cases satisfied the criteria of primary GI tract lymphoma at 
      presentation or operation. Four showed a close relationship to human T-cell 
      lymphotropic virus type I (HTLV-I). Those four had positive results for 
      anti-HTLV-I antibody and positive surface markers for CD4, positive hybridization 
      signals by ISH, and HTLV-I gene products by PCR, but they had no lymphoma cells 
      in peripheral blood or bone marrow. The fifth case showed negative signals by ISH 
      and PCR. CONCLUSIONS: These findings suggest that some of the putative adult 
      T-cell leukemia/lymphoma (ATLL) types can be further classified as GI-tract-type 
      lymphoma. The prognosis for the GI tract type is as poor as it is for 
      conventional ATLL.
FAU - Tokunaga, O
AU  - Tokunaga O
AD  - Department of Pathology, Saga Medical School, Japan.
FAU - Watanabe, T
AU  - Watanabe T
FAU - Shimamoto, Y
AU  - Shimamoto Y
FAU - Tokudome, S
AU  - Tokudome S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (DNA Probes)
RN  - 0 (HTLV-I Antibodies)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Base Sequence
MH  - DNA Probes
MH  - Female
MH  - Gastrointestinal Neoplasms/*microbiology/pathology
MH  - HTLV-I Antibodies/analysis
MH  - HTLV-I Infections/genetics/immunology
MH  - Human T-lymphotropic virus 1/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - *In Situ Hybridization
MH  - Lymphoma, T-Cell/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - *Polymerase Chain Reaction
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1002/1097-0142(19930201)71:3<708::aid-cncr2820710309>3.0.co;2-p [doi]
PST - ppublish
SO  - Cancer. 1993 Feb 1;71(3):708-16. doi: 
      10.1002/1097-0142(19930201)71:3<708::aid-cncr2820710309>3.0.co;2-p.