PMID- 8432777
OWN - NLM
STAT- MEDLINE
DCOM- 19930317
LR  - 20201209
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 76
IP  - 2
DP  - 1993 Feb
TI  - Effect of variations in dietary fat and carbohydrate intake on postprandial 
      lipemia in patients with noninsulin dependent diabetes mellitus.
PG  - 347-51
AB  - The effect of dietary composition on concentrations of postprandial lipoproteins 
      was studied in eight sulfonylurea-treated patients with noninsulin dependent 
      diabetes mellitus. Two diets were consumed by each patient for 2 weeks in random 
      order, one contained (as percent of total calories) 15% protein, 40% fat, and 45% 
      carbohydrate (CHO), whereas the other consisted of 15% protein, 25% fat, and 60% 
      CHO. At the end of each dietary period, patients were given Vitamin A (60,000 
      U/m2) with their noon meal, and the concentration of triglyceride (TG) and 
      retinyl esters in plasma and two lipoprotein fractions (Sf > 400 and Sf 20-400) 
      determined over the next 12 h. The results indicated that both postprandial TG 
      and retinyl ester concentrations were higher in plasma (Sf > 400, and Sf 20-400 
      lipoproteins), when patients ate the 25% fat/60% CHO diet. Thus, replacing 
      saturated fat with CHO accentuates the magnitude of postprandial lipemia. Since 
      TG-rich lipoproteins may be atherogenic, appropriate dietary advice for patients 
      with type 2 diabetes may deserve reappraisal.
FAU - Chen, Y D
AU  - Chen YD
AD  - Department of Medicine, Stanford University School of Medicine, California.
FAU - Swami, S
AU  - Swami S
FAU - Skowronski, R
AU  - Skowronski R
FAU - Coulston, A M
AU  - Coulston AM
FAU - Reaven, G M
AU  - Reaven GM
LA  - eng
GR  - HL-08506/HL/NHLBI NIH HHS/United States
GR  - RR-00070/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - 0 (Diterpenes)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins)
RN  - 0 (Retinyl Esters)
RN  - 0 (Triglycerides)
RN  - 11103-57-4 (Vitamin A)
RN  - 1D1K0N0VVC (retinol palmitate)
SB  - IM
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Dietary Proteins/administration & dosage
MH  - Diterpenes
MH  - *Food
MH  - Humans
MH  - Insulin/blood
MH  - Lipids/*blood
MH  - Lipoproteins/blood
MH  - Male
MH  - Middle Aged
MH  - Retinyl Esters
MH  - Triglycerides/blood
MH  - Vitamin A/administration & dosage/analogs & derivatives/blood
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1210/jcem.76.2.8432777 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1993 Feb;76(2):347-51. doi: 10.1210/jcem.76.2.8432777.