PMID- 8435203
OWN - NLM
STAT- MEDLINE
DCOM- 19930322
LR  - 20220316
IS  - 0959-8049 (Print)
IS  - 0959-8049 (Linking)
VI  - 29A
IP  - 4
DP  - 1993
TI  - HLA antigen frequencies in renal transplant recipients and non-immunosuppressed 
      patients with non-melanoma skin cancer.
PG  - 520-4
AB  - An increased frequency of human leukocyte antigen (HLA)-DR1 was found in 49 
      non-immunosuppressed patients with non-melanoma skin cancer (NMSC), being highest 
      in patients under the age of 60 with multiple squamous cell carcinomas (SCC). Of 
      266 patients receiving long-term immunosuppression following renal 
      transplantation 46 (17%) were found to have NMSC. No increase in HLA-DR1 was 
      found in renal transplant recipients (RTR) with non-melanoma skin cancer (RTR+C) 
      when compared with matched renal transplant recipients without skin cancer 
      (matched RTR-C), or when compared with healthy controls. There was an increased 
      frequency of DQw2 in RTR+C, most pronounced in RTR with SCC (61.9% compared with 
      18.75% in matched RTR-C), giving a relative risk of 13.98. We found statistically 
      significant differences in the frequency of a number of HLA antigens on comparing 
      RTR+C with healthy controls, but none of these differences were found when we 
      compared RTR+C against matched RTR-C.
FAU - Glover, M T
AU  - Glover MT
AD  - Department of Dermatology, Royal London Hospital, U.K.
FAU - Bodmer, J
AU  - Bodmer J
FAU - Bodmer, W
AU  - Bodmer W
FAU - Kennedy, L J
AU  - Kennedy LJ
FAU - Brown, J
AU  - Brown J
FAU - Navarrete, C
AU  - Navarrete C
FAU - Kwan, J T
AU  - Kwan JT
FAU - Leigh, I M
AU  - Leigh IM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR1 Antigen)
SB  - IM
MH  - Antigens, Neoplasm/*analysis
MH  - Carcinoma, Basal Cell/*immunology
MH  - Carcinoma, Squamous Cell/*immunology
MH  - Female
MH  - HLA Antigens/*analysis
MH  - HLA-DQ Antigens/analysis
MH  - HLA-DR1 Antigen/analysis
MH  - Humans
MH  - Immunosuppression Therapy
MH  - Kidney Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/etiology
MH  - Risk Factors
MH  - Skin Neoplasms/etiology/*immunology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - S0959-8049(05)80143-1 [pii]
AID - 10.1016/s0959-8049(05)80143-1 [doi]
PST - ppublish
SO  - Eur J Cancer. 1993;29A(4):520-4. doi: 10.1016/s0959-8049(05)80143-1.