PMID- 8440518
OWN - NLM
STAT- MEDLINE
DCOM- 19930330
LR  - 20131121
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 27
IP  - 1
DP  - 1993 Mar
TI  - Excitotoxic amino acid injections into the medial amygdala facilitate maternal 
      behavior in virgin female rats.
PG  - 56-81
AB  - The inhibitory role of the medial amygdala (MA) in maternal behavior control was 
      explored. Injections of N-methyl-D,L-aspartic acid (NMA), an excitotoxic amino 
      acid, into the MA resulted in a dramatic facilitation of maternal behavior in 
      virgin female rats when pups were presented to them 12 days following the 
      injections. This effect was specific to MA in that NMA injections into the 
      basolateral amygdala were ineffective. The facilitatory effect of NMA injections 
      into MA was found to be hormone dependent in that ovariectomies abolished the 
      effect. Subsequent experiments provided evidence that NMA injections into MA 
      induced a pseudopregnant state lasting about 13 days, and that maternal behavior 
      was greatly facilitated only when pups were presented to such females coincident 
      with pseudopregnancy termination. When pups were presented 24 days following 
      injections of NMA into MA, rather than 12 days, only a modest facilitation of 
      maternal behavior was observed. It was concluded that NMA injections into MA 
      influence maternal behavior in two ways: By inducing an hormonal state 
      stimulatory for maternal behavior and by removing neural inhibition over maternal 
      behavior.
FAU - Numan, M
AU  - Numan M
AD  - Department of Psychology, Boston College, Chestnut Hill, Massachusetts 02167.
FAU - Numan, M J
AU  - Numan MJ
FAU - English, J B
AU  - English JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 3A64E3G5ZO (Bromocriptine)
RN  - 6384-92-5 (N-Methylaspartate)
SB  - IM
MH  - Amygdala/*drug effects/physiology
MH  - Animals
MH  - Brain Mapping
MH  - Bromocriptine/pharmacology
MH  - Estrus/drug effects/physiology
MH  - Female
MH  - *Maternal Behavior
MH  - N-Methylaspartate/*pharmacology/physiology
MH  - Neural Inhibition/*drug effects/physiology
MH  - Pseudopregnancy/physiopathology
MH  - Rats
MH  - Sexual Maturation/drug effects/physiology
MH  - Social Environment
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
AID - S0018-506X(83)71005-6 [pii]
AID - 10.1006/hbeh.1993.1005 [doi]
PST - ppublish
SO  - Horm Behav. 1993 Mar;27(1):56-81. doi: 10.1006/hbeh.1993.1005.