PMID- 8440877
OWN - NLM
STAT- MEDLINE
DCOM- 19930330
LR  - 20190920
IS  - 0260-437X (Print)
IS  - 0260-437X (Linking)
VI  - 13
IP  - 1
DP  - 1993 Jan-Feb
TI  - Effect of propane-1,2-diol ingestion on carbohydrate metabolism in female rat 
      erythrocytes.
PG  - 69-75
AB  - This study was undertaken to assess the effect of propane-1,2-diol(PD) ingestion 
      on carbohydrate metabolism in female rat erythrocytes. For this purpose, two 
      different groups of adult albino female rats were treated orally with PD at two 
      different dose levels of 73 and 294 mg 100 g-1 body wt. The blood samples drawn 
      from the retro-orbital sinus prior to the treatment served as the controls, 
      whereas the treated samples were collected at peak periods (1/2 and 2 h) 2 and 7 
      days after the treatment. A single dose of PD was found to elevate levels of 
      blood glucose, lactate, pyruvate and the lactate/pyruvate ratio at the peak 
      periods (P < 0.001) and after 2 days (P < 0.001) in both the groups. A 
      significant (P < 0.05) increase in the contents of erythrocyte 
      2,3-diphosphoglycerate (2,3-DPG) was observed only at the peak periods. All these 
      parameters returned to their base level after 7 days of treatment. The activities 
      of hexokinase (HK), 2,3-diphosphoglycerate phosphatase (2,3-DPG Pase), lactate 
      dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PD), 
      6-phosphogluconate dehydrogenase (6-PGD) and aldehyde reductase II (AR II) 
      declined markedly, whereas those of pyruvate kinase (PK) and aldose reductase 
      increased as a result of PD ingestion. The changes in the activities of 2,3-DPG 
      Pase and LDH were persistent up to 8 days post-treatment. The [14C]glucose flux 
      through glycolysis and the hexose monophosphate shunt pathway in erythrocytes was 
      found to be lowered (P < 0.001) in response to PD treatment.(ABSTRACT TRUNCATED 
      AT 250 WORDS)
FAU - Saini, M
AU  - Saini M
AD  - Department of Biochemistry, Panjab University, Chandigarh, India.
FAU - Nagpaul, J P
AU  - Nagpaul JP
FAU - Amma, M K
AU  - Amma MK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Appl Toxicol
JT  - Journal of applied toxicology : JAT
JID - 8109495
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Blood Glucose)
RN  - 0 (Carbohydrates)
RN  - 0 (Propylene Glycols)
RN  - 6DC9Q167V3 (Propylene Glycol)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Blood Glucose/metabolism
MH  - Carbohydrates/*blood
MH  - Erythrocytes/drug effects/*metabolism
MH  - Female
MH  - Glycolysis/drug effects
MH  - In Vitro Techniques
MH  - Pentose Phosphate Pathway/drug effects
MH  - Propylene Glycol
MH  - Propylene Glycols/*pharmacology
MH  - Rats
MH  - Rats, Wistar
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1002/jat.2550130114 [doi]
PST - ppublish
SO  - J Appl Toxicol. 1993 Jan-Feb;13(1):69-75. doi: 10.1002/jat.2550130114.