PMID- 8443802
OWN - NLM
STAT- MEDLINE
DCOM- 19930407
LR  - 20061115
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 53
IP  - 6
DP  - 1993 Mar 15
TI  - Regulation of fibroblast hepatocyte growth factor/scatter factor expression by 
      human breast carcinoma cell lines and peptide growth factors.
PG  - 1233-8
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is a stromally derived modulator 
      of epithelial cell proliferation and morphology. To better assess the potential 
      role of HGF/SF in tumor progression we sought to identify factors and biological 
      conditions which regulate its expression. We show that several adult human 
      primary fibroblast cultures from breast and prostate produce HGF/SF. HGF 
      expression in the MRC-5 human fetal lung fibroblast cell line is stimulated by 
      conditioned media harvested from human breast tumor cell lines (MCF-7, T47D, and 
      MDA-MB-231). In contrast, both indirect and direct coculture of each of these 
      tumor lines with MRC-5 fibroblasts down-regulates HGF/SF expression. Finally, we 
      show that MRC-5 HGF expression is inhibited by several known peptide growth 
      factors, including transforming growth factor beta, epidermal growth factor, and 
      transforming growth factor alpha.
FAU - Seslar, S P
AU  - Seslar SP
AD  - Department of Anatomy and Cell Biology, Georgetown University, Washington, DC 
      20007.
FAU - Nakamura, T
AU  - Nakamura T
FAU - Byers, S W
AU  - Byers SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Growth Substances)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Breast Neoplasms/*physiopathology
MH  - Culture Media, Conditioned
MH  - Female
MH  - Fibroblasts/physiology
MH  - Growth Substances/*pharmacology
MH  - Hepatocyte Growth Factor/*biosynthesis/physiology
MH  - Humans
MH  - Tumor Cells, Cultured
EDAT- 1993/03/15 00:00
MHDA- 1993/03/15 00:01
CRDT- 1993/03/15 00:00
PHST- 1993/03/15 00:00 [pubmed]
PHST- 1993/03/15 00:01 [medline]
PHST- 1993/03/15 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1993 Mar 15;53(6):1233-8.