PMID- 8445226
OWN - NLM
STAT- MEDLINE
DCOM- 19930405
LR  - 20190817
IS  - 0168-8278 (Print)
IS  - 0168-8278 (Linking)
VI  - 17
IP  - 1
DP  - 1993 Jan
TI  - Effects of carbohydrate intake on the blood ethanol level and alcoholic fatty 
      liver damage in rats.
PG  - 97-101
AB  - Effects of carbohydrate (CHO) intake on the blood ethyl alcohol (ethanol) level 
      were studied in rats with a surgically placed gastric cannula. A basal diet 
      (protein, 2.07; fat, 1.98; CHO, 5.76 g/day), a high-CHO diet (CHO, 4.39 g/day) + 
      ethanol, a medium-CHO diet (CHO, 2.69 g/day) + ethanol or a low-CHO diet (CHO, 
      0.98 g/day) + ethanol was infused into the stomach for 4 weeks starting from the 
      2nd postoperative week. The basal diet and the test diets were isocaloric, and 
      the ethanol (2.80 g/day) in the test diets accounted for 39% of the total 
      calories. The liquid diets (50 kcal in 50 ml) were infused over 16 h from 16.00 
      to 08.00 h each day. The low-CHO diet group had significantly higher blood 
      ethanol levels than the high-CHO diet group 4, 8 and 16 h after the start of 
      infusion. These groups could be ranked by liver triglyceride content at autopsy 
      as follows: low-CHO > medium-CHO > high-CHO > or = basal. Consistent with the 
      triglyceride content, histological changes of the liver could be ranked by the 
      degree of fatty changes in the same order: low-CHO > medium-CHO > high-CHO > 
      basal. Thus, for a given amount of ethanol consumption, lower CHO intake was 
      associated with higher blood ethanol levels and with more severe fatty changes of 
      the liver.
FAU - Yonekura, I
AU  - Yonekura I
AD  - Department of Environmental Health, Medical University of Yamanashi, Japan.
FAU - Nakano, M
AU  - Nakano M
FAU - Sato, A
AU  - Sato A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Lipids)
RN  - 0 (Phospholipids)
RN  - 0 (Triglycerides)
RN  - 3K9958V90M (Ethanol)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Cholesterol/analysis
MH  - *Dietary Carbohydrates
MH  - Ethanol/*blood
MH  - Fatty Liver, Alcoholic/pathology/*physiopathology
MH  - Lipids/*analysis
MH  - Liver/chemistry/pathology
MH  - Male
MH  - Organ Size
MH  - Phospholipids/analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
MH  - Triglycerides/analysis
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - S0168-8278(05)80528-8 [pii]
AID - 10.1016/s0168-8278(05)80528-8 [doi]
PST - ppublish
SO  - J Hepatol. 1993 Jan;17(1):97-101. doi: 10.1016/s0168-8278(05)80528-8.