PMID- 8445229
OWN - NLM
STAT- MEDLINE
DCOM- 19930408
LR  - 20190817
IS  - 0168-8278 (Print)
IS  - 0168-8278 (Linking)
VI  - 17
IP  - 2
DP  - 1993 Feb
TI  - Absence or delayed appearance of hepatitis B core antibody in chronic hepatitis B 
      surface antigen carrier children.
PG  - 150-4
AB  - An absence of the hepatitis B core antibody (anti-HBc) in hepatitis B surface 
      antigen (HBsAg) carrier children has been reported before, but whether anti-HBc 
      will ultimately appear is unknown. In a group of 420 HBsAg carrier children who 
      were followed longitudinally, 10 (2.4%) had an absence or delayed appearance of 
      serum anti-HBc. These 10 children were persistently seropositive for HBsAg, 
      hepatitis B e-antigen, and hepatitis B virus DNA (HBV-DNA). Anti-HBc never 
      appeared in 4, one of whom was a case of hepatitis B vaccine failure and became 
      an HBsAg carrier. Three of the 4 were born to HBsAg carrier mothers. Liver biopsy 
      in one revealed non-specific reactive hepatitis (NSRH). All 4 were asymptomatic 
      during follow-up. Mothers of the other 6 children who had delayed appearance of 
      anti-HBc were also HBsAg carriers. The children seroconverted to anti-HBc 
      positivity between 2 and 8 years of age, and the titer of serum anti-HBc at the 
      first appearance varied. There were no significant changes in liver function 
      tests, HBV-DNA levels, or associated symptoms and signs before and after 
      seroconversion. Liver biopsies were performed before anti-HBc seroconversion in 2 
      children and showed NSRH. All 10 children had a moderate to high replication of 
      HBV as shown by the high titer of HBsAg and HBV-DNA. The absence of anti-HBc 
      occurred almost exclusively in children who were infected perinatally.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Ni, Y H
AU  - Ni YH
AD  - Department of Pediatrics, College of Medicine, National Taiwan University, 
      Taipei, Republic of China.
FAU - Hsu, H Y
AU  - Hsu HY
FAU - Chang, M H
AU  - Chang MH
FAU - Chen, D S
AU  - Chen DS
FAU - Lee, C Y
AU  - Lee CY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (Biomarkers)
RN  - 0 (DNA, Viral)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Core Antigens)
RN  - 0 (Hepatitis B Surface Antigens)
SB  - IM
MH  - Biomarkers/blood
MH  - Carrier State/*immunology
MH  - Child
MH  - Child, Preschool
MH  - DNA, Viral/analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Hepatitis B/*immunology
MH  - Hepatitis B Antibodies/*blood
MH  - Hepatitis B Core Antigens/*immunology
MH  - Hepatitis B Surface Antigens/*blood
MH  - Hepatitis B virus/genetics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Liver/pathology/physiopathology
MH  - Male
MH  - Time Factors
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - S0168-8278(05)80030-3 [pii]
AID - 10.1016/s0168-8278(05)80030-3 [doi]
PST - ppublish
SO  - J Hepatol. 1993 Feb;17(2):150-4. doi: 10.1016/s0168-8278(05)80030-3.