PMID- 8445386
OWN - NLM
STAT- MEDLINE
DCOM- 19930402
LR  - 20071114
IS  - 0022-3034 (Print)
IS  - 0022-3034 (Linking)
VI  - 24
IP  - 2
DP  - 1993 Feb
TI  - Distribution of pluripotent neural crest cells in the embryo and the role of 
      brain-derived neurotrophic factor in the commitment to the primary sensory neuron 
      lineage.
PG  - 173-84
AB  - Many early migratory neural crest cells are pluripotent in the sense that their 
      progeny are able to generate more than one differentiated phenotype (Sieber-Blum 
      and Cohen, 1980, Dev. Biol. 80:95-106; Baroffio, Dupin, and Le Douarin, 1988, 
      Proc. Natl. Acad. Sci. USA 85:5325-5329; Bronner-Fraser and Fraser, 1988, Nature 
      335:161-164; Sieber-Blum, 1989a, Science 243:1608-1611; Ito and Sieber-Blum, 
      1991, Dev. Biol. 148:95-106). At trunk levels, the neural crest contains two 
      classes (Sieber-Blum and Cohen, 1980) and at posterior rhombencephalic levels, 
      three different classes of pluripotent cells (Ito and Sieber-Blum, 1991). We 
      investigated cell differentiation by in vitro clonal analysis to determine when 
      in development the pool of pluripotent neural crest cells becomes exhausted. The 
      data suggest that different classes of pluripotent cells, precursor cells with 
      more restricted developmental potentials, and apparently committed cells, exist 
      at sites of advanced migration (posterior branchial arches) and even at target 
      sites of neural crest cell differentiation [posterior branchial arches, dorsal 
      root ganglia (DRG), sympathetic ganglia (SG), and epidermal ectoderm]. Some 
      putative classes of pluripotent cells persist well into the second half of 
      embryonic development. These observations have implications for our understanding 
      of the mechanisms that control neural crest cell migration and differentiation. 
      They support the idea that cues originating from the microenvironment affect 
      differentiation of pluripotent neural crest cells. One such signal appears to be 
      brain-derived neurotrophic factor (BDNF). In the presence of BDNF, but not nerve 
      growth factor (NGF), there is a significant increase in the number of neural 
      crest cells per colony that express a sensory neuron-specific marker. Because 
      this increase is not accompanied by a corresponding increase in the total number 
      of cells per colony, this suggests that BDNF plays a role in cell type 
      specification.
FAU - Sieber-Blum, M
AU  - Sieber-Blum M
AD  - Department of Cellular Biology and Anatomy, Medical College of Wisconsin, 
      Milwaukee 53226.
FAU - Ito, K
AU  - Ito K
FAU - Richardson, M K
AU  - Richardson MK
FAU - Langtimm, C J
AU  - Langtimm CJ
FAU - Duff, R S
AU  - Duff RS
LA  - eng
GR  - HD21423/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurobiol
JT  - Journal of neurobiology
JID - 0213640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Clone Cells
MH  - Ectoderm/cytology/physiology
MH  - Embryo, Nonmammalian
MH  - Ganglia, Spinal/cytology/embryology
MH  - Nerve Growth Factors/pharmacology
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Neural Crest/*cytology/drug effects/*physiology
MH  - Neurons, Afferent/*cytology/drug effects/physiology
MH  - Quail
MH  - Signal Transduction
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1002/neu.480240205 [doi]
PST - ppublish
SO  - J Neurobiol. 1993 Feb;24(2):173-84. doi: 10.1002/neu.480240205.