PMID- 8446929
OWN - NLM
STAT- MEDLINE
DCOM- 19930408
LR  - 20071114
IS  - 0040-3709 (Print)
IS  - 0040-3709 (Linking)
VI  - 47
IP  - 2
DP  - 1993 Feb
TI  - Evaluation of the bioeffects of prenatal ultrasound exposure in the cynomolgus 
      macaque (Macaca fascicularis): III. Developmental and hematologic studies.
PG  - 159-70
AB  - The multiple applications of diagnostic ultrasound in obstetrics have resulted in 
      a continued rise in the prenatal population exposed each year. Although human 
      epidemiologic and experimental studies with various animal models have not 
      consistently documented any significant, reproducible findings related to 
      clinically relevant exposures, technologic changes in scanning equipment and gaps 
      in our knowledge regarding the interaction(s) of ultrasound with tissues 
      emphasize the need to pursue safety issues. Studies with nonhuman primates have 
      provided information on the potential for pre and postnatal effects on offspring 
      exposed repeatedly during gestation (ATL MK 600, 7.5 MHz, ISPTA = 27 mW/cm2; 
      ISPPA = 85 W/cm2; Estimated power = 12 mW--scanned for 10 min 5 times weekly 
      gestational day [GD] 20-35; 3 times weekly GD 36-60; once weekly for 20 min GD 
      60-150). These studies have indicated transient effects on body weight, white 
      blood cell counts (WBCs), and muscle tone postnatally. In an effort to confirm 
      these findings and focus on hematologic changes, a second series of studies was 
      initiated using the same exposure conditions (N = 22; 11 exposed, 11 sham 
      controls). Data derived from both studies were combined and confirmed transient 
      reductions in body weights for infants up through 4 months of age (P < or = 
      0.03); no statistically significant differences in muscle tone were noted. 
      Similar to the original findings, WBCs were transiently reduced on days 3 (P < or 
      = 0.02) and 21 (P < or = 0.05); prenatal sampling indicated a significant 
      difference between the groups on GD 140 (P < or = 0.04). No direct effects were 
      evident in bone marrow aspirates collected on postnatal days 3, 9, and 21 +/- 1. 
      Although animals were able to compensate for these observed changes and remained 
      unaffected by their occurrence, additional studies will be required to further 
      our understanding of this phenomenon.
FAU - Tarantal, A F
AU  - Tarantal AF
AD  - California Regional Primate Research Center, University of California, Davis 
      95616.
FAU - O'Brien, W D
AU  - O'Brien WD
FAU - Hendrickx, A G
AU  - Hendrickx AG
LA  - eng
GR  - HD25528/HD/NICHD NIH HHS/United States
GR  - RR00169/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Teratology
JT  - Teratology
JID - 0153257
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal
MH  - Body Weight
MH  - Embryonic and Fetal Development
MH  - Female
MH  - Gestational Age
MH  - Hematopoiesis
MH  - Leukocyte Count
MH  - Macaca fascicularis
MH  - Muscle Tonus
MH  - Pregnancy
MH  - Safety
MH  - Ultrasonography, Prenatal/*adverse effects
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1002/tera.1420470208 [doi]
PST - ppublish
SO  - Teratology. 1993 Feb;47(2):159-70. doi: 10.1002/tera.1420470208.