PMID- 8450374
OWN - NLM
STAT- MEDLINE
DCOM- 19930413
LR  - 20221207
IS  - 0277-2116 (Print)
IS  - 0277-2116 (Linking)
VI  - 16
IP  - 2
DP  - 1993 Feb
TI  - Association between HLA and extrahepatic biliary atresia.
PG  - 114-7
AB  - The etiopathogenesis of extrahepatic biliary atresia (EHBA) remains undefined. 
      There are clinical and pathological suggestions supporting the idea that EHBA 
      could consist of at least two forms: the congenital (embryonic or fetal) and the 
      acquired (perinatal) types. To test the hypothesis that susceptibility to this 
      disease would be influenced by host genetic factors, we studied the human 
      leukocyte antigen (HLA) system in 55 patients with and without major extrahepatic 
      congenital anomalies. We found, especially in those without associated 
      malformations, a significantly higher frequency of HLA-B12, of haplotypes A9-B5 
      and A28-B35, and of their disequilibrium values, as compared with the 8th 
      International Histocompatibility Workshop controls. This study suggests that 
      immunogenetic factors may play a role in determining susceptibility to EHBA, and 
      the different HLA frequencies in those with and without anomalies lend support to 
      the hypothesis that biliary atresia may be an etiologically heterogeneous 
      disorder.
FAU - Silveira, T R
AU  - Silveira TR
AD  - Departamento de Pediatria, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, Brazil.
FAU - Salzano, F M
AU  - Salzano FM
FAU - Donaldson, P T
AU  - Donaldson PT
FAU - Mieli-Vergani, G
AU  - Mieli-Vergani G
FAU - Howard, E R
AU  - Howard ER
FAU - Mowat, A P
AU  - Mowat AP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (HLA Antigens)
SB  - IM
CIN - J Pediatr Gastroenterol Nutr. 1993 Feb;16(2):111-3. PMID: 8450373
MH  - Biliary Atresia/complications/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Congenital Abnormalities/immunology
MH  - Europe
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/*blood/genetics
MH  - Haplotypes
MH  - Humans
MH  - Infant
MH  - Male
MH  - White People
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1097/00005176-199302000-00002 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 1993 Feb;16(2):114-7. doi: 
      10.1097/00005176-199302000-00002.