PMID- 8450600
OWN - NLM
STAT- MEDLINE
DCOM- 19930414
LR  - 20190817
IS  - 0047-1828 (Print)
IS  - 0047-1828 (Linking)
VI  - 57
IP  - 2
DP  - 1993 Feb
TI  - Hemodynamic effects of milrinone in patients with congestive heart 
      failure--short- and long-term follow up studies.
PG  - 91-101
AB  - The hemodynamic effects of milrinone (Mil) were studied in 11 patients with 
      congestive heart failure (CHF) and New York Heart Association (NYHA) functional 
      class II-IV before and after a 2-week treatment. The plasma concentration of Mil 
      was also determined and its pharmacokinetics analyzed. The effect of a placebo 
      was examined before the initiation of the treatment. At the onset, the 
      hemodynamic effects of a single oral dose of Mil (7.5 mg) were evaluated. Mil 
      increased the cardiac index significantly (p < 0.05) 4 h after administrations 
      from 2.3 +/- 0.4 to 2.9 +/- 0.6 L/min/m2. The pulmonary capillary wedge pressure 
      (PCW) was lowered significantly by Mil (p < 0.05) between 0.5 and 4 h after 
      administration. After a 2-week treatment, the baseline PCW dropped (p < 0.05) and 
      the NYHA functional class improved in 10 patients. One patient remained in the 
      same class (II). The improved NYHA class was maintained in 6 patients tested 
      after a mean interval of 16 +/- 3 months. Single oral administration of Mil (7.5 
      mg) induced hemodynamic improvements after 2-week treatment and the drug also 
      induced similar improvements even after the chronic oral therapy with Mil for 16 
      +/- 3 months. Pharmacokinetic analysis showed a significant increase in the area 
      under the curve after 2 weeks of treatment. We conclude that Mil decreases the 
      PCW and probably increases the cardiac index and thus improves the symptoms and 
      NYHA functional class in patients with CHF.
FAU - Nanimatsu, H
AU  - Nanimatsu H
AD  - Department of Medicine, Oita Prefectural Hospital, Japan.
FAU - Saikawa, T
AU  - Saikawa T
FAU - Maeda, T
AU  - Maeda T
FAU - Fukuoka, Y
AU  - Fukuoka Y
FAU - Takaki, R
AU  - Takaki R
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Jpn Circ J
JT  - Japanese circulation journal
JID - 7806868
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Pyridones)
RN  - 0 (Vasodilator Agents)
RN  - JU9YAX04C7 (Milrinone)
SB  - IM
MH  - Aged
MH  - Cardiotonic Agents/*therapeutic use
MH  - Drug Evaluation
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*drug therapy
MH  - Hemodynamics/*drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Milrinone
MH  - Pulmonary Wedge Pressure/drug effects
MH  - Pyridones/blood/pharmacokinetics/*therapeutic use
MH  - Vasodilator Agents/*therapeutic use
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1253/jcj.57.91 [doi]
PST - ppublish
SO  - Jpn Circ J. 1993 Feb;57(2):91-101. doi: 10.1253/jcj.57.91.