PMID- 8451291
OWN - NLM
STAT- MEDLINE
DCOM- 19930415
LR  - 20190818
IS  - 0031-8655 (Print)
IS  - 0031-8655 (Linking)
VI  - 57
IP  - 2
DP  - 1993 Feb
TI  - Modulation of interferon-gamma-induced HLA-DR expression on the human 
      keratinocyte cell line SCC-13 by ultraviolet radiation.
PG  - 285-90
AB  - Cell surface expression of major histocompatibility determinants on epidermal 
      keratinocytes is a characteristic feature of a number of inflammatory dermatoses 
      and in all likelihood is caused by diffusion of human leukocyte antigen 
      (HLA)-DR-inducing cytokines from cells present in the dermal mononuclear cell 
      infiltrate. Many of these same disorders respond to ultraviolet (UV) radiation 
      phototherapy. Using the human SCC-13 keratinocyte cell line as a model, UV 
      radiation was found to inhibit interferon-gamma-induced HLA-DR expression. 
      Inhibition correlated closely with decreased steady-state levels of HLA-DR mRNA. 
      These findings provide evidence that the therapeutic effect of UV radiation 
      phototherapy may be mediated by its capacity to down-regulate cytokine-induced 
      keratinocyte HLA-DR expression.
FAU - Khan, I U
AU  - Khan IU
AD  - Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106.
FAU - Boehm, K D
AU  - Boehm KD
FAU - Elmets, C A
AU  - Elmets CA
LA  - eng
GR  - K04-AR01765/AR/NIAMS NIH HHS/United States
GR  - P30-CA43703/CA/NCI NIH HHS/United States
GR  - R01-AR32593/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Photochem Photobiol
JT  - Photochemistry and photobiology
JID - 0376425
RN  - 0 (HLA-DR Antigens)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 82115-62-6 (Interferon-gamma)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Cell Line
MH  - Dinoprostone/pharmacology
MH  - Dose-Response Relationship, Radiation
MH  - Genes, MHC Class II/radiation effects
MH  - HLA-DR Antigens/biosynthesis/*genetics
MH  - Humans
MH  - Indomethacin/pharmacology
MH  - Interferon-gamma/*pharmacology
MH  - Keratinocytes/immunology/*radiation effects
MH  - RNA, Messenger/metabolism
MH  - Recombinant Proteins
MH  - *Ultraviolet Rays
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1111/j.1751-1097.1993.tb02288.x [doi]
PST - ppublish
SO  - Photochem Photobiol. 1993 Feb;57(2):285-90. doi: 
      10.1111/j.1751-1097.1993.tb02288.x.