PMID- 8452581
OWN - NLM
STAT- MEDLINE
DCOM- 19930412
LR  - 20190718
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 36
IP  - 3
DP  - 1993 Mar
TI  - Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer 
      in patients with Wegener's granulomatosis.
PG  - 365-71
AB  - OBJECTIVE: To assess the correlation and prognostic value of antineutrophil 
      cytoplasmic antibody (cANCA) titers with disease activity in patients with 
      Wegener's granulomatosis (WG). METHODS: One hundred six patients with WG had 
      serum ANCA determinations; 72 had serial titers obtained routinely at 1-3-month 
      intervals. One hundred twelve subjects (19 of whom were healthy donors) served as 
      controls. All serum samples were tested for cANCA by an indirect 
      immunofluorescence technique. A prospective analysis of disease activity and 
      cANCA values was performed. Disease activity was assessed according to clinical, 
      laboratory, radiographic, and histopathologic findings. RESULTS: Positivity for 
      cANCA was a sensitive (88%) marker of active WG. However, changes in serial 
      titers temporally correlated with a change in disease status in only 64% of 
      patients. Furthermore, an increase in the cANCA titer preceded clinical 
      exacerbation of disease in only 24% of patients who had been in remission or had 
      low-grade, smoldering disease. CONCLUSION: A rise in cANCA titer alone should not 
      be considered adequate evidence of an impending clinical exacerbation, and 
      therefore does not justify initiating or increasing immunosuppressive therapy.
FAU - Kerr, G S
AU  - Kerr GS
AD  - Laboratory of Immunoregulation, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Fleisher, T A
AU  - Fleisher TA
FAU - Hallahan, C W
AU  - Hallahan CW
FAU - Leavitt, R Y
AU  - Leavitt RY
FAU - Fauci, A S
AU  - Fauci AS
FAU - Hoffman, G S
AU  - Hoffman GS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - VB0R961HZT (Prednisone)
SB  - IM
CIN - Arthritis Rheum. 1994 Apr;37(4):596-7. PMID: 8147939
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Autoantibodies/*analysis
MH  - Biomarkers
MH  - Cyclophosphamide/therapeutic use
MH  - False Positive Reactions
MH  - Fluorescent Antibody Technique
MH  - Follow-Up Studies
MH  - Granulomatosis with Polyangiitis/drug therapy/*immunology/pathology
MH  - Humans
MH  - Immunoglobulin G/*analysis
MH  - Predictive Value of Tests
MH  - Prednisone/therapeutic use
MH  - Prognosis
MH  - Prospective Studies
MH  - Sensitivity and Specificity
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
AID - 10.1002/art.1780360312 [doi]
PST - ppublish
SO  - Arthritis Rheum. 1993 Mar;36(3):365-71. doi: 10.1002/art.1780360312.