PMID- 8453034
OWN - NLM
STAT- MEDLINE
DCOM- 19930416
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 4
IP  - 1
DP  - 1993 Jan
TI  - Neurotrophin-3 upregulates NGF receptors in a central nervous system glial cell 
      line.
PG  - 33-6
AB  - The low-affinity nerve growth factor (NGF) receptor (LNGFR) binds the 
      neurotrophins NGF, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 
      (NT-3) with similar affinities. Here we report on the ability of NT-3 to regulate 
      the expression of the LNGFR in C6 glioma cells. LNGFR-like immunoreactivity 
      (LNGFR-IR) was examined in C6 cells treated for 16 h with NT-3 and exposed to the 
      antibody 192-IgG followed by immunoglobulins conjugated with colloidal gold by 
      means of ultrastructural morphometric analysis. Untreated C6 cells exhibited some 
      positive LNGFR-IR, while C6 cells treated with NT-3 displayed significantly 
      increased (2.3 fold) LNGFR-IR. The increase in LNGFR protein was accompanied by a 
      greater quantity of LNGFR mRNA in NT-3-treated cells. Thus, LNGFR can be 
      upregulated by the structurally related neurotrophin NT-3.
FAU - Spoerri, P E
AU  - Spoerri PE
AD  - Fidia Research Laboratories, Fidia S.p.A., Abano Terme, Italy.
FAU - Romanello, S
AU  - Romanello S
FAU - Petrelli, L
AU  - Petrelli L
FAU - Negro, A
AU  - Negro A
FAU - Guidolin, D
AU  - Guidolin D
FAU - Skaper, S D
AU  - Skaper SD
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Brain Chemistry
MH  - Cell Line
MH  - Glioma/metabolism
MH  - Microscopy, Immunoelectron
MH  - Nerve Growth Factors/*pharmacology
MH  - Nervous System Neoplasms/metabolism
MH  - Neuroglia/drug effects/*metabolism
MH  - Neurotrophin 3
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Receptors, Nerve Growth Factor/*drug effects
MH  - Recombinant Proteins/pharmacology
MH  - Tumor Cells, Cultured
MH  - Up-Regulation/*drug effects
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1097/00001756-199301000-00008 [doi]
PST - ppublish
SO  - Neuroreport. 1993 Jan;4(1):33-6. doi: 10.1097/00001756-199301000-00008.