PMID- 8453057
OWN - NLM
STAT- MEDLINE
DCOM- 19930422
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 4
IP  - 2
DP  - 1993 Feb
TI  - MK801 induces immediate-early gene proteins and BDNF mRNA in rat cerebrocortical 
      neurones.
PG  - 183-6
AB  - Recent studies have shown that MK801, a potent phencyclidine receptor ligand, 
      causes pathomorphological changes in rat cerebrocortical neurones. Here we report 
      that doses of MK801 (1 and 5 mg kg-1) which have been shown to produce 
      pathomorphological changes, induce the expression of immediate-early gene 
      proteins (IEGPs) and brain-derived neurotrophic factor (BDNF) mRNA in rat 
      cerebrocortical neurones. Blockade of central muscarinic receptors which has been 
      shown to prevent MK801-induced pathomorphological changes in cerebrocortical 
      neurones, also prevented MK801-induced expression of IEGPs and BDNF mRNA. The 
      transiently increased expression of BDNF mRNA may be an acute compensatory 
      response of these neurones to MK801-induced injury.
FAU - Hughes, P
AU  - Hughes P
AD  - Department of Pharmacology, School of Medicine, University of Auckland, New 
      Zealand.
FAU - Dragunow, M
AU  - Dragunow M
FAU - Beilharz, E
AU  - Beilharz E
FAU - Lawlor, P
AU  - Lawlor P
FAU - Gluckman, P
AU  - Gluckman P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Egr1 protein, rat)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Cerebral Cortex/drug effects/*physiology
MH  - DNA-Binding Proteins/analysis/genetics
MH  - Dizocilpine Maleate/*pharmacology
MH  - Early Growth Response Protein 1
MH  - Genes, fos/drug effects
MH  - Genes, jun/drug effects
MH  - *Immediate-Early Proteins
MH  - In Situ Hybridization
MH  - Male
MH  - Nerve Growth Factors/genetics
MH  - Nerve Tissue Proteins/*genetics
MH  - Neurons/drug effects/*physiology
MH  - Proto-Oncogene Proteins c-fos/analysis/genetics
MH  - Proto-Oncogene Proteins c-jun/analysis/genetics
MH  - Proto-Oncogenes/*drug effects
MH  - RNA, Messenger/analysis/genetics/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Transcription Factors/analysis/genetics
MH  - Zinc Fingers/genetics
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1097/00001756-199302000-00017 [doi]
PST - ppublish
SO  - Neuroreport. 1993 Feb;4(2):183-6. doi: 10.1097/00001756-199302000-00017.