PMID- 8453478
OWN - NLM
STAT- MEDLINE
DCOM- 19930416
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 603
IP  - 1
DP  - 1993 Feb 12
TI  - Functional role of brain AT1 and AT2 receptors in the central angiotensin II 
      pressor response.
PG  - 57-63
AB  - Intracerebroventricular (i.c.v.) angiotensin II (ANG II) increases vascular 
      resistance and elicits a pressor response characterized by sympathetic nervous 
      system activation (SNS component) and increased vasopressin (VP) secretion (VP 
      component). This study examines the role of brain AT1 and AT2 ANG II receptors in 
      mediating the pressor and renal hemodynamic effects of i.c.v. ANG II in conscious 
      Sprague-Dawley rats. Mean arterial pressure, heart rate and renal vascular 
      resistance responses to i.c.v. ANG II (100 ng in 5 microliters) were determined 
      10 min after i.c.v. injection of either the AT1 receptor antagonist, DuP 753 
      (1.0, 2.5, 5.0, 10.0 micrograms), the AT2 receptor ligand, PD 123319 (3.5 x 
      [10(-6), 10(-4), 10(-2), 10(0)] micrograms), or both. In control rats, i.c.v. DuP 
      753 prevented the pressor response and the increase in renal vascular resistance 
      that occurred following i.c.v. ANG II in a dose-dependent manner (P < 0.05), 
      while i.c.v. PD 123319 was without affect. When the VP- and SNS components were 
      studied individually, by preventing the SNS component with intravenous (i.v.) 
      chlorisondamine or the VP component with a V1 receptor antagonist (i.v.) similar 
      results were obtained; DuP 753 prevented the SNS component and significantly 
      reduced the VP component. These results indicate that both central ANG II pressor 
      components are mediated primarily by brain AT1 receptors. However, doses of DuP 
      753 were more effective when combined with 3.5 micrograms of PD 123319 than when 
      given alone (P < 0.05), suggesting that the pressor effects of i.c.v. ANG II may 
      involve activation of multiple ANG II receptor subtypes.
FAU - Toney, G M
AU  - Toney GM
AD  - Department of Pharmacology, University of Texas Health Science Center, San 
      Antonio 78282-7764.
FAU - Porter, J P
AU  - Porter JP
LA  - eng
GR  - R29 HL38993/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Imidazoles)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, Angiotensin)
RN  - 0 (Tetrazoles)
RN  - 11128-99-7 (Angiotensin II)
RN  - 130663-39-7 (PD 123319)
RN  - 9041-90-1 (Angiotensin I)
RN  - JD3M24F66I (Chlorisondamine)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Angiotensin I/*metabolism
MH  - Angiotensin II/antagonists & inhibitors/*metabolism/pharmacology
MH  - Angiotensin Receptor Antagonists
MH  - Animals
MH  - Biphenyl Compounds/pharmacology
MH  - Blood Pressure/*drug effects
MH  - Brain/drug effects/*physiology
MH  - Chlorisondamine/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Heart Rate/drug effects
MH  - Imidazoles/pharmacology
MH  - Injections, Intraventricular
MH  - Losartan
MH  - Male
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Angiotensin/*physiology
MH  - Renal Circulation/drug effects
MH  - Tetrazoles/pharmacology
EDAT- 1993/02/12 00:00
MHDA- 1993/02/12 00:01
CRDT- 1993/02/12 00:00
PHST- 1993/02/12 00:00 [pubmed]
PHST- 1993/02/12 00:01 [medline]
PHST- 1993/02/12 00:00 [entrez]
AID - 0006-8993(93)91299-8 [pii]
AID - 10.1016/0006-8993(93)91299-8 [doi]
PST - ppublish
SO  - Brain Res. 1993 Feb 12;603(1):57-63. doi: 10.1016/0006-8993(93)91299-8.