PMID- 8457082
OWN - NLM
STAT- MEDLINE
DCOM- 19930422
LR  - 20170214
IS  - 0003-3197 (Print)
IS  - 0003-3197 (Linking)
VI  - 44
IP  - 4
DP  - 1993 Apr
TI  - Three-month therapy with calcium-heparin in comparison with ticlopidine in 
      patients with peripheral arterial occlusive disease at Leriche-Fontaine IIb 
      class.
PG  - 307-13
AB  - Forty patients with a mean age of 62.6 +/- 6 years, 36 men and 4 women, with 
      peripheral arterial occlusive disease (PAOD) at Leriche-Fontaine IIb class, were 
      randomly allocated to one of two treatment groups, receiving either 12,500 IU/day 
      of subcutaneous (sc) calcium-heparin (CAE) or 250 mg/day of oral ticlopidine, 
      each given for ninety days. The following parameters were evaluated before the 
      start of the active treatment period and after thirty and ninety days of 
      treatment: pain-free walking distance (PWD), maximum walking distance (WDmax), 
      systolic and diastolic blood pressure (BP), posterior tibial arterial pressure 
      and Winsor index at rest and after exercise (treadmill), transcutaneous oxygen 
      and carbon dioxide pressures at rest (TcPO2 and TcPCO2 respectively), and time to 
      50% TcPO2 recovery after three-minute ischemia. Both treatments induced an 
      improvement in PWD/WDmax, which, at the end of the study, were increased by 
      50.7/58.7% and 31.7/36.2%, respectively, for CAE and ticlopidine treatments, 
      respectively.
FAU - Andreozzi, G M
AU  - Andreozzi GM
AD  - Chair of Angiology, University of Catania, Italy.
FAU - Signorelli, S S
AU  - Signorelli SS
FAU - Cacciaguerra, G
AU  - Cacciaguerra G
FAU - Di Pino, L
AU  - Di Pino L
FAU - Martini, R
AU  - Martini R
FAU - Monaco, S
AU  - Monaco S
FAU - Butto, G
AU  - Butto G
FAU - Sardina, M
AU  - Sardina M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Fibrinolytic Agents)
RN  - 37270-89-6 (calcium heparin)
RN  - 9005-49-6 (Heparin)
RN  - OM90ZUW7M1 (Ticlopidine)
SB  - IM
MH  - Arterial Occlusive Diseases/diagnosis/*drug therapy
MH  - Blood Gas Monitoring, Transcutaneous
MH  - Exercise Test
MH  - Female
MH  - Fibrinolytic Agents/*therapeutic use
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peripheral Vascular Diseases/diagnosis/*drug therapy
MH  - Ticlopidine/*therapeutic use
MH  - Time Factors
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 10.1177/000331979304400407 [doi]
PST - ppublish
SO  - Angiology. 1993 Apr;44(4):307-13. doi: 10.1177/000331979304400407.