PMID- 8462607
OWN - NLM
STAT- MEDLINE
DCOM- 19930504
LR  - 20190825
IS  - 0340-6997 (Print)
IS  - 0340-6997 (Linking)
VI  - 20
IP  - 3
DP  - 1993 Mar
TI  - Evaluation of white cell scintigraphy using indium-111 and technetium-99m 
      labelled leucocytes.
PG  - 201-6
AB  - Indium-111 oxine labelled leucocyte (111In oxine leucocyte) scintigraphy is the 
      test of choice in detecting occult infection and localising focal inflammation. 
      111In oxine labelling is technically difficult and expensive and leucocyte 
      labelling with technetium-99m stannous colloid (99mTc Sn colloid) has been 
      considered to be an alternative. Leucocytes from 40 cases referred for 
      investigation of occult infection or localisation of inflammation were 
      simultaneously labelled with 111In oxine and 99mTc Sn colloid with dual isotope 
      acquisition performed at 1, 3 and 24 h. Twenty-four hour 99mTc Sn colloid scans 
      were corrected for 111In downscatter. Each case was independently interpreted by 
      two experienced observers. Twenty-one patients demonstrated positive 111In oxine 
      leucocyte scans. Using 111In oxine leucocyte scans as the gold standard, 99mTc Sn 
      colloid leucocyte scanning had an overall sensitivity of 86% and a specificity of 
      95%. Clinical follow-up verified that three patients had false negative 99mTc Sn 
      colloid leucocyte scans and one patient had a false positive. Further clinical 
      evaluation of 99mTc Sn colloid labelled leucocytes is required before they can 
      become a reliable replacement for 111In oxine leucocytes.
FAU - Boyd, S J
AU  - Boyd SJ
AD  - Department of Nuclear Medicine, St. George Hospital, Kogarah, Australia.
FAU - Nour, R
AU  - Nour R
FAU - Quinn, R J
AU  - Quinn RJ
FAU - McKay, E
AU  - McKay E
FAU - Butler, S P
AU  - Butler SP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Eur J Nucl Med
JT  - European journal of nuclear medicine
JID - 7606882
RN  - 0 (Colloids)
RN  - 0 (Indium Radioisotopes)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Technetium Compounds)
RN  - 0 (Tin Compounds)
RN  - 0 (technetium Tc 99m tin colloid)
RN  - 14514-42-2 (indium oxine)
RN  - 5UTX5635HP (Oxyquinoline)
RN  - 7440-26-8 (Technetium)
RN  - 7440-31-5 (Tin)
SB  - IM
MH  - Colloids
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Focal Infection/*diagnostic imaging/epidemiology
MH  - Humans
MH  - *Indium Radioisotopes
MH  - Inflammation/*diagnostic imaging/epidemiology
MH  - *Leukocytes
MH  - Male
MH  - Middle Aged
MH  - *Organometallic Compounds
MH  - Oxyquinoline/*analogs & derivatives
MH  - Predictive Value of Tests
MH  - Radionuclide Imaging
MH  - Sensitivity and Specificity
MH  - *Technetium
MH  - *Technetium Compounds
MH  - Time Factors
MH  - *Tin
MH  - *Tin Compounds
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
AID - 10.1007/BF00169999 [doi]
PST - ppublish
SO  - Eur J Nucl Med. 1993 Mar;20(3):201-6. doi: 10.1007/BF00169999.