PMID- 8463392
OWN - NLM
STAT- MEDLINE
DCOM- 19930506
LR  - 20210526
IS  - 0095-1137 (Print)
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Linking)
VI  - 31
IP  - 4
DP  - 1993 Apr
TI  - Evaluation of immunoglobulin E-specific antibodies and viral antigens in 
      nasopharyngeal secretions of children with respiratory syncytial virus 
      infections.
PG  - 819-23
AB  - Enzyme immunoassays were developed to detect the presence of specific 
      immunoglobulin E (IgE) antibodies and respiratory syncytial (RS) virus structural 
      proteins in nasopharyngeal secretions in order to improve the knowledge on some 
      aspects of the pathogenesis of severe acute lower respiratory tract infections 
      caused by RS virus. These assays were used to analyze clinical specimens from 
      children with RS virus-associated infections (bronchiolitis and pneumonia), and 
      the findings were correlated with the patients' clinical symptoms. The results 
      indicate the presence of specific IgE against the two external glycoproteins (G 
      and F) and the absence of detectable IgE levels for the internal viral antigens. 
      There was a correlation between the levels of IgE-specific antibodies and the 
      amount of viral protein F in the secretions, indicating that the IgE response 
      against the viral glycoproteins might be related to the antigen load. In 
      addition, a correlation was found between higher levels of both viral protein 
      F-specific IgE and F antigen with higher respiratory rates in children with 
      pneumonia. These findings may be relevant because they suggest an association 
      between the virus load and the immune response in the pathogenesis of RS virus 
      infections.
FAU - Russi, J C
AU  - Russi JC
AD  - Departamento de Laboratorios, Ministerio de Salud Publica, Montevideo, Uruguay.
FAU - Delfraro, A
AU  - Delfraro A
FAU - Borthagaray, M D
AU  - Borthagaray MD
FAU - Velazquez, B
AU  - Velazquez B
FAU - Garcia-Barreno, B
AU  - Garcia-Barreno B
FAU - Hortal, M
AU  - Hortal M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (HN Protein)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (Viral Proteins)
RN  - 0 (attachment protein G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies, Viral/analysis
MH  - Antigens, Viral/*analysis/immunology
MH  - Child, Preschool
MH  - *HN Protein
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Infant
MH  - Infant, Newborn
MH  - Nasopharynx/*microbiology
MH  - Respiratory Syncytial Viruses/*immunology
MH  - Respirovirus Infections/*immunology
MH  - Seasons
MH  - Viral Envelope Proteins
MH  - Viral Proteins/*analysis/immunology
PMC - PMC263570
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
PMCR- 1993/04/01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
PHST- 1993/04/01 00:00 [pmc-release]
AID - 10.1128/jcm.31.4.819-823.1993 [doi]
PST - ppublish
SO  - J Clin Microbiol. 1993 Apr;31(4):819-23. doi: 10.1128/jcm.31.4.819-823.1993.