PMID- 8465384
OWN - NLM
STAT- MEDLINE
DCOM- 19930506
LR  - 20190512
IS  - 0035-9203 (Print)
IS  - 0035-9203 (Linking)
VI  - 87
IP  - 1
DP  - 1993 Jan-Feb
TI  - Relationship between the degree of poverty and the IgE response to Ascaris 
      infection in slum children.
PG  - 16-8
AB  - We examined a group of urban slum children in Caracas, Venezuela, and 
      demonstrated the relationship that exists between poverty, conditions of hygiene 
      and the prevalence of helminth infection. Concordant with the high prevalence of 
      helminth infection in these children, the total serum levels of immunoglobulin E 
      (IgE) and blood eosinophilia were elevated and were directly related to the 
      degree of poverty and lack of sanitary facilities. However, in contrast, the 
      reverse pattern was observed for the specific allergic response to these 
      parasites. Thus, the immediate hypersensitivity skin test reactivity to Ascaris 
      antigens, and the serum levels of specific anti-Ascaris IgE antibody, were lowest 
      in the poorest children, who had the highest prevalence of helminth infection and 
      the highest total IgE levels. As allergic-type reactions may participate in 
      protective mechanisms against helminths, these results suggest that poverty and 
      poor sanitary conditions may, by influencing the IgE response, compromise the 
      resistance of such children to parasitic infections.
FAU - Hagel, I
AU  - Hagel I
AD  - Institute of Biomedicine, Faculty of Medicine, Central University of Venezuela, 
      Caracas.
FAU - Lynch, N R
AU  - Lynch NR
FAU - Perez, M
AU  - Perez M
FAU - Di Prisco, M C
AU  - Di Prisco MC
FAU - Lopez, R
AU  - Lopez R
FAU - Rojas, E
AU  - Rojas E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Trans R Soc Trop Med Hyg
JT  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JID - 7506129
RN  - 0 (Antibodies, Helminth)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Helminth/*blood
MH  - Ascariasis/blood/*epidemiology/immunology
MH  - Ascaris lumbricoides/*immunology
MH  - Child
MH  - Feces/parasitology
MH  - Humans
MH  - Hygiene
MH  - Immunoglobulin E/*blood
MH  - Parasite Egg Count
MH  - *Poverty
MH  - Poverty Areas
MH  - Prevalence
MH  - Public Health
MH  - Venezuela/epidemiology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1016/0035-9203(93)90401-b [doi]
PST - ppublish
SO  - Trans R Soc Trop Med Hyg. 1993 Jan-Feb;87(1):16-8. doi: 
      10.1016/0035-9203(93)90401-b.