PMID- 8465772
OWN - NLM
STAT- MEDLINE
DCOM- 19930504
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 125
IP  - 4
DP  - 1993 Apr
TI  - Additional antianginal efficacy of amiodarone in patients with limiting angina 
      pectoris.
PG  - 996-1001
AB  - Sixty-three patients with stable angina New York Heart Association (NYHA) class 
      III and a positive stress test despite triple therapy were randomized to a 
      double-blind protocol, receiving either placebo or amiodarone in a dose of 600 
      mg/day for 10 days, followed by 400 mg/day for an additional 10 days, and then by 
      200 mg/day over a total period of 2 months. Comparable bicycle exercise times 
      were observed at baseline in the amiodarone group (6.0 +/- 1.6 minutes) and in 
      the placebo group (6.0 +/- 1.8 minutes). With amiodarone, there was a increase in 
      exercise duration of 6.7 +/- 2.2 minutes versus 6.3 +/- 2.2 minutes at 1 month 
      and 7.5 +/- 2.1 minutes versus 6.2 +/- 1.7 minutes at 2 months (p < 0.05). Also, 
      the amiodarone group had a significant decrease in the double product when 
      compared with the placebo group at 1 month (14,134 +/- 3,316 versus 17,570 +/- 
      4,092 mm Hg/min, p < 0.001) and at 2 months (14,022 +/- 3,303 and 17,298 +/- 
      4,872 mm Hg/min, p < 0.001). The degree of ST segment depression at peak exercise 
      was also significantly reduced. Combination therapy of amiodarone with 
      conventional antianginal therapy is well tolerated and results in a significant 
      improvement in exercise capacity and a mild reduction of symptoms in patients who 
      have continued, limiting angina pectoris with conventional triple therapy.
FAU - Meyer, B J
AU  - Meyer BJ
AD  - Department of Medicine, University Hospital Zurich, Switzerland.
FAU - Amann, F W
AU  - Amann FW
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Thyroid Hormones)
RN  - N3RQ532IUT (Amiodarone)
SB  - IM
MH  - Aged
MH  - Amiodarone/*therapeutic use
MH  - Angina Pectoris/blood/*drug therapy/physiopathology
MH  - Blood Pressure
MH  - Double-Blind Method
MH  - Exercise Test
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Thyroid Hormones/blood
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 0002-8703(93)90106-J [pii]
AID - 10.1016/0002-8703(93)90106-j [doi]
PST - ppublish
SO  - Am Heart J. 1993 Apr;125(4):996-1001. doi: 10.1016/0002-8703(93)90106-j.