PMID- 8465816
OWN - NLM
STAT- MEDLINE
DCOM- 19930504
LR  - 20220310
IS  - 0272-6386 (Print)
IS  - 0272-6386 (Linking)
VI  - 21
IP  - 4
DP  - 1993 Apr
TI  - A race-controlled human leukocyte antigen frequency analysis in lupus nephritis. 
      The South-Eastern Organ Procurement Foundation.
PG  - 378-82
AB  - Systemic lupus erythematosus (SLE) has higher incidence and mortality rates in 
      addition to a greater risk for nephropathy in African Americans (blacks), 
      compared with whites. We analyzed the South-Eastern Organ Procurement Foundation 
      (SEOPF) database from 1982 through 1986 to determine if variation in human 
      leukocyte antigen (HLA) frequencies, beyond those normally present between the 
      races, were associated with lupus nephritis (LN). HLA antigen frequencies in 271 
      black and 230 white renal transplant recipients with LN as the cause of end-stage 
      renal disease (ESRD) were compared with 4,506 race-matched cadaveric kidney donor 
      controls. Odds ratios (ORs) and chi-square values were computed to assess the 
      prevalence of each HLA phenotype among the cases versus the controls separately 
      for blacks and whites. HLA-B8 and -DR2 frequencies were increased, and HLA-DR4 
      frequency was decreased in cases of both races compared with race-matched 
      controls (race-combined ORs, 1.68, 1.46, and 0.49, respectively; all P < 0.01). 
      Race-specific analyses showed that HLA-DR6 was decreased in black cases versus 
      black controls (OR, 0.48; P < 0.001) and HLA-DR3 was increased in white cases 
      versus white controls (OR, 1.88; P < 0.001). HLA-B8 and DR2 are positively 
      associated and HLA-DR4 is negatively associated with LN in patients of both 
      races. HLA-DR3 and -DR6 demonstrate race-specificity in LN and place whites at a 
      disadvantage relative to blacks. It is likely that non-HLA-mediated genetic 
      factors and/or environmental factors contribute to the increased risk of 
      nephritis observed in black patients with SLE.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Freedman, B I
AU  - Freedman BI
AD  - Department of Medicine, Bowman Gray School of Medicine of Wake Forest University, 
      Winston-Salem, NC 27157-1053.
FAU - Spray, B J
AU  - Spray BJ
FAU - Heise, E R
AU  - Heise ER
FAU - Espeland, M A
AU  - Espeland MA
FAU - Canzanello, V J
AU  - Canzanello VJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney 
      Foundation
JID - 8110075
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Chi-Square Distribution
MH  - HLA Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Kidney Failure, Chronic/ethnology/etiology/*immunology
MH  - Kidney Transplantation/immunology
MH  - Lupus Nephritis/complications/ethnology/*immunology
MH  - Odds Ratio
MH  - Phenotype
MH  - Racial Groups/*genetics
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - S0272638693000575 [pii]
AID - 10.1016/s0272-6386(12)80264-2 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 1993 Apr;21(4):378-82. doi: 10.1016/s0272-6386(12)80264-2.