PMID- 8467479
OWN - NLM
STAT- MEDLINE
DCOM- 19930507
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 66
IP  - 1
DP  - 1993 Mar
TI  - FISH: a useful technique in the verification of clonality of random chromosome 
      abnormalities.
PG  - 73-4
AB  - Random chromosome abnormality is an important issue in clinical cytogenetics, 
      especially in cancer cytogenetics. The significance of random abnormalities needs 
      to be well defined. In the present study, ten patients with malignant hematologic 
      disorders were analyzed by classical cytogenetic techniques and fluorescence in 
      situ hybridization (FISH) procedures. Cytogenetic studies showed all ten patients 
      to have a single cell with trisomy, i.e., +8, +8 (5 cases), +12, +15, +18, +20, 
      and +21, respectively. FISH necessitated revision of the cytogenetic diagnosis 
      and confirmed the clonality of these "random" abnormalities.
FAU - Chen, Z
AU  - Chen Z
AD  - Cancer Center of Genetrix, Inc. Scottsdale, Arizona 85251.
FAU - Morgan, R
AU  - Morgan R
FAU - Stone, J F
AU  - Stone JF
FAU - Sandberg, A A
AU  - Sandberg AA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Leukemia/*genetics
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
MH  - Myeloproliferative Disorders/*genetics
MH  - Trisomy
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
AID - 0165-4608(93)90152-C [pii]
AID - 10.1016/0165-4608(93)90152-c [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1993 Mar;66(1):73-4. doi: 10.1016/0165-4608(93)90152-c.