PMID- 8469420
OWN - NLM
STAT- MEDLINE
DCOM- 19930513
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 150
IP  - 2
DP  - 1993 Feb 19
TI  - Influence of interleukin-1 and tumor necrosis factor alpha on the growth of 
      microglial cells in primary cultures of mouse cerebral cortex: involvement of 
      colony-stimulating factor 1.
PG  - 195-9
AB  - The influence of monokines and CNS-derived colony-stimulating factors (CSF) on 
      the growth of microglia has been studied in mixed glial primary cultures stemming 
      from mouse embryos. We observed that spontaneous growth of microglial cells in 
      the presence of astrocytes is blocked by adding anti-colony-stimulating factor 1 
      (CSF-1) antibodies to the cultures. Both interleukin-1 (IL-1) and tumor necrosis 
      factor-alpha(TNF alpha) strongly increased the number of microglial cells in 
      mixed glial cultures and this effect was prevented by anti-CSF-1 antibodies. In 
      contrast, anti-interleukin-3 (IL-3) or anti-granulocyte-macrophage 
      colony-stimulating factor (GM-CSF) antibodies did not significantly affect the in 
      vitro growth of microglia. These results provide functional significance to 
      astrocytic productions of CSF-1 and their modulations by IL-1 or TNF alpha.
FAU - Thery, C
AU  - Thery C
AD  - INSERM U114, Chaire de Neuropharmacologie, College de France, Paris.
FAU - Mallat, M
AU  - Mallat M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Colony-Stimulating Factors)
RN  - 0 (Interleukin-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Astrocytes/drug effects/metabolism
MH  - Cells, Cultured
MH  - Cerebral Cortex/*cytology/drug effects/embryology
MH  - Colony-Stimulating Factors/*pharmacology
MH  - Female
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology
MH  - Immunohistochemistry
MH  - Interleukin-1/*pharmacology
MH  - Mice
MH  - Neuroglia/*drug effects
MH  - Pregnancy
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1993/02/19 00:00
MHDA- 1993/02/19 00:01
CRDT- 1993/02/19 00:00
PHST- 1993/02/19 00:00 [pubmed]
PHST- 1993/02/19 00:01 [medline]
PHST- 1993/02/19 00:00 [entrez]
AID - 0304-3940(93)90534-R [pii]
AID - 10.1016/0304-3940(93)90534-r [doi]
PST - ppublish
SO  - Neurosci Lett. 1993 Feb 19;150(2):195-9. doi: 10.1016/0304-3940(93)90534-r.