PMID- 8472836
OWN - NLM
STAT- MEDLINE
DCOM- 19930520
LR  - 20131121
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 6
IP  - 3
DP  - 1993 Mar
TI  - Occupational asthma due to zinc.
PG  - 447-50
AB  - We describe a subject who developed asthma symptoms 2 yrs after being employed at 
      a plant where metals were galvanized in heated zinc. The subject was not atopic. 
      Baseline spirometry was normal three months after he left work but there was mild 
      bronchial hyperresponsiveness to methacholine. Monitoring of forced expiratory 
      volume in one second (FEV1) during a day at work showed a maximum fall in FEV1 of 
      24% at the end of the day and an increase in bronchial responsiveness on the 
      following day. Environmental monitoring revealed that zinc and iron were present 
      in the working environment at concentrations that were lower than the "threshold 
      limit value-short term exposure level" (TLV-STEL) standards. Positive immediate 
      skin tests to zinc sulphate at concentrations of 1 and 10 mg.ml-1 were obtained, 
      although no specific immunoglobulin E (IgE) antibodies to zinc could be found. 
      Skin tests with copper, chromium and cobalt were negative. Specific inhalation 
      challenges were performed, having the subject inhale a solution of zinc sulphate 
      at a 10 mg.ml-1 concentration for 6 min. An immediate reaction was elicited 
      (maximum fall in FEV1 of 23%). We conclude that zinc can cause occupational 
      asthma.
FAU - Malo, J L
AU  - Malo JL
AD  - Dept of Chest Medicine, Hopital du Sacre-Coeur, Montreal, Canada.
FAU - Cartier, A
AU  - Cartier A
FAU - Dolovich, J
AU  - Dolovich J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Asthma/*chemically induced/diagnosis/epidemiology
MH  - Bronchial Provocation Tests
MH  - Humans
MH  - Male
MH  - Metallurgy
MH  - Middle Aged
MH  - Occupational Diseases/*chemically induced/diagnosis/epidemiology
MH  - Occupational Exposure
MH  - Quebec/epidemiology
MH  - Radioallergosorbent Test
MH  - Skin Tests
MH  - Spirometry
MH  - Time Factors
MH  - Zinc/*adverse effects
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1993 Mar;6(3):447-50.