PMID- 8485991
OWN - NLM
STAT- MEDLINE
DCOM- 19930610
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 63
IP  - 3
DP  - 1993
TI  - Interstitial localization of telomeric DNA sequences in the Indian muntjac 
      chromosomes: further evidence for tandem chromosome fusions in the karyotypic 
      evolution of the Asian muntjacs.
PG  - 156-9
AB  - The Indian muntjac is believed to have the lowest chromosome number in mammals 
      (2n = 6 in females and 2n = 7 in males). It has been suggested that a series of 
      tandem chromosome fusions from an ancestral Chinese muntjac-like species (2n = 
      46) may have occurred during the karyotypic evolution of the Indian muntjac. In 
      an earlier study, hybridization signals generated by the Chinese muntjac 
      centromeric heterochromatin DNA probe (C5) were found to be distributed 
      interstitially in the chromosomes of the Indian muntjac, providing supportive 
      evidence for the tandem chromosome fusion theory. In this study, the highly 
      conserved human telomeric DNA sequence (TTAGGG)n was localized by fluorescence in 
      situ hybridization (FISH) on the metaphase chromosomes of three Cervidae species: 
      the Indian muntjac, Chinese muntjac, and woodland caribou. As expected, 
      hybridization signals were observed at the termini of almost every chromosome in 
      all three species. In addition, interstitial hybridization signals were detected 
      in chromosomes 1 and 2 of the Indian muntjac. The observed interstitial telomeric 
      signals appeared to correspond to specific interstitial centromeric 
      heterochromatin sites. These interstitial telomeric signals could represent 
      remnant DNA sequences from the ancestral species telomeres, further supporting 
      the tandem chromosome fusion theory. Furthermore, these observations permit the 
      elucidation of the chromosome sites where breakage and fusion most likely 
      occurred during the restructuring of the ancestral Chinese muntjac-like 
      chromosomes to form the present day Indian muntjac karyotype.
FAU - Lee, C
AU  - Lee C
AD  - Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, 
      Canada.
FAU - Sasi, R
AU  - Sasi R
FAU - Lin, C C
AU  - Lin CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Heterochromatin)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Biological Evolution
MH  - Chromosomes/*ultrastructure
MH  - Deer/*genetics
MH  - Heterochromatin/ultrastructure
MH  - In Situ Hybridization
MH  - Karyotyping
MH  - Telomere/*chemistry
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1159/000133525 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1993;63(3):156-9. doi: 10.1159/000133525.