PMID- 8489210
OWN - NLM
STAT- MEDLINE
DCOM- 19930610
LR  - 20041117
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 33
IP  - 4
DP  - 1993 Apr
TI  - Isolation of HTLV-II from a patient with chronic, progressive neurological 
      disease clinically indistinguishable from HTLV-I-associated myelopathy/tropical 
      spastic paraparesis.
PG  - 392-6
AB  - An increasing spectrum of diseases has been shown to be associated with the human 
      T-cell lymphotropic virus type I (HTLV-I), most notably a chronic, progressive 
      myelopathy termed HTLV-I--associated myelopathy/tropical spastic paraparesis and 
      adult T-cell leukemia. HTLV-II is a close relative of HTLV-I and is structurally 
      similar but molecularly distinct. This virus is endemic in Amerindian populations 
      and a high seroprevalence rate has been observed in intravenous drug abusers. 
      Here, for the first time, we have identified a patient with a chronic, 
      progressive neurological disease clinically indistinguishable from 
      HTLV-I--associated myelopathy/tropical spastic paraparesis from whom we have 
      isolated and characterized HTLV-II in the absence of any other detectable human 
      retrovirus. Antibodies to HTLV were detected in both serum and cerebrospinal 
      fluid, with typical HTLV-II banding patterns on Western blots. HTLV-II viral 
      sequences were detected in high copy number from peripheral lymphocytes by 
      polymerase chain reaction techniques, and cloning and sequencing of this virus 
      revealed a 99.5% homology with prototype HTLV-II. These results serve to alert 
      the medical community to the possibility that in addition to HTLV-I, HTLV-II may 
      be associated with a neurological disorder.
FAU - Jacobson, S
AU  - Jacobson S
AD  - Neuroimmunology Branch, NIH, Bethesda, MD 20892.
FAU - Lehky, T
AU  - Lehky T
FAU - Nishimura, M
AU  - Nishimura M
FAU - Robinson, S
AU  - Robinson S
FAU - McFarlin, D E
AU  - McFarlin DE
FAU - Dhib-Jalbut, S
AU  - Dhib-Jalbut S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Brain/pathology
MH  - Chronic Disease
MH  - DNA, Viral/analysis/genetics
MH  - Human T-lymphotropic virus 2/genetics/*isolation & purification
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/diagnosis/*microbiology/*physiopathology
MH  - Nucleic Acid Hybridization
MH  - Paraparesis, Tropical Spastic/*physiopathology
MH  - Sequence Homology, Nucleic Acid
MH  - Spinal Cord/pathology
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 10.1002/ana.410330411 [doi]
PST - ppublish
SO  - Ann Neurol. 1993 Apr;33(4):392-6. doi: 10.1002/ana.410330411.